Researchers, bless them, have done the obvious at last and published it in the February 26 New England Journal of Medicine (and here’s how USA Today explains the study). They put some intrepid volunteers on 1400-calorie diets varying in content of protein (15-25%), fat (20-40%), and carbohydrate (35-65%) and waited to see how much weight they would lose by the end of two years. Ta-da! The participants all lost a lot of weight in 6 months, but slowly gained it back. By the end of 2 years, they lost about the same amount of weight regardless of the mix. Conclusion: when it comes to weight loss, how much you eat matters more than what you eat. Or, as I am fond of saying, if you want to lose weight, eat less!