by Marion Nestle

Search results: seralini

Dec 2 2013

What’s up with the retraction of the Séralini feeding-GMO-corn-to-rats study?

The big news over the weekend was that the journal, Food and Chemical Toxicology, announced that it is retracting the paper it published last year by Séralini et al.

The Séralini paper claimed that feeding genetically modified corn to female rats, with or without added Roundup, caused them to develop more mammary tumors than rats that were not fed GMO corn.

As I discussed in a post at the time, I had my doubts about the scientific quality of the Séralini study.  The findings were based on a small number of animals, were not dose-dependent and failed to exclude the possibility that they could have occurred by chance.

In response to readers’ queries about my critique of the science, I added a clarification:

I very much favor research on this difficult question.   There are enough questions about this study to suggest the need for repeating it, or something like it, under carefully controlled conditions.

In science, repeating someone else’s study is common practice.  Retracting a published paper is not. The editors of Food and Chemical Technology say they are retracting the paper because its findings are inconclusive.

The low number of animals had been identified as a cause for concern during the initial review process, but the peer-review decision ultimately weighed that the work still had merit despite this limitation.  A more in-depth look at the raw data revealed that no definitive conclusions can be reached with this small sample size regarding the role of either NK603 or glyphosate in regards to overall mortality or tumor incidence. Given the known high incidence of tumors in the Sprague-Dawley rat, normal variability cannot be excluded as the cause of the higher mortality and incidence observed in the treated groups.

Hello.  Where were they during the peer review process?  Editors decide whether papers get published.  The editors chose to publish the study, even though they had just published a meta-analysis coming to the opposite conclusion: “GM plants are nutritionally equivalent to their non-GM counterparts and can be safely used in food and feed.”

Now, in response to a barrage of criticism (see letters accompanying the online version of the Séralini study), the editors have given its authors an ultimatum: withdraw the paper (which Séralini says he will not do), or they will retract it.

But the editor wrote Séralini:

Unequivocally, the Editor-in-Chief found no evidence of fraud or intentional misrepresentation of the data.

Then how come the retraction?  Guidelines for retracting journal articles published by the Committee on Publication Ethics (COPE) say:

 Journal editors should consider retracting a publication if:

  • They have clear evidence that the findings are unreliable, either as a result of misconduct (e.g. data fabri­cation) or honest error (e.g. miscalculation or experimental error)
  • The findings have previously been published elsewhere without proper crossreferencing, permission or justification (i.e. cases of redundant publication)
  • It constitutes plagiarism
  • It reports unethical research

The Séralini paper may be unreliable, but that should have been obvious to the peer reviewers and the journal’s editors.  Otherwise, the paper does not fit any of the established criteria for retraction.

The anti-GMO group, GM Watch, points out that Food and Chemical Technology is a member of COPE.  On this basis, it says the journal’s retraction of the study is ”illicit, unscientific, and unethical.”  It has a point.

This is a mess, with the journal’s editors clearly at fault.  At this point, they should:

  • Admit that the journal’s peer review—and editorial—processes are deeply flawed.
  • State that the journal never should have accepted the paper in the first place.
  • Announce immediate steps to correct the flawed review processes.
  • Apologize to Séralini et al. for having caved in to pressure and blaming him, rather than themselves, for the mess.
  • Publish all documentation about the paper on the journal’s website.
  • Call on the scientific community to repeat the Séralini study with populations of rats large enough to permit statistical analyses of the results.

About the documentation:

  • Séralini, according to a scathing account of this affair in Forbes, plans to sue Food and Chemical Technology for breach of protocol.  The Forbes piece finds ”

    The entire episode, including the oddly worded retraction statement…a black eye for the beleaguered journal and Elsevier [the publisher].”

  • GM Watch posted the “oddly-worded-retraction” letter (from the editor to Séralini) but then took it down.  While the link was still active, I took a screenshot.  I wish I’d copied the whole thing.  If anyone knows where to it, please send the link.

Screenshot 2013-11-28 10.29.58

Additions

  • Thanks to a reader for sending the entire letter from editor Hayes to Séralini.
  • Another reader sent this article suggesting that appointment of a Monsanto-connected editor to the journal may have led to the retraction.
Jan 29 2019

My latest honor: “Crankster!”

I don’t usually pay attention to what the American Council for Science and Health (ACSH) says or does, mainly because it is a long-standing front group for the food and chemical industries, and it predictably supports the interests of those industries over public health (see US Right to Know’s analysis).

But then I read this from the Center on Media and Democracy: Corporate Front Group, American Council on Science and Health, Smears List of Its Enemies as “Deniers for Hire.”

Smeared by the site are scientists Tyrone Hayes, Stephanie Seneff, and Gilles-Éric Séralini; New York Times reporter Danny Hakim and columnist Mark Bittman; well-known food and science writer Michael Pollan; nutrition and food studies professor Marion Nestle; public interest groups like U.S. Right to Know, Greenpeace, Natural Resources Defense Council (NRDC), Sierra Club, the Environmental Working Group, and Union of Concerned Scientists; past and present CMD staff, and many other individuals ACSH does not like.

Clearly, I’m in good company.  But what, exactly, have I—a “Crankster,” apparently—done to deserve this honor?  It seems that I:

What can I say?  Read my work and decide for yourself if such concerns are justified.

Mar 21 2015

WHO’s cancer working group: Roundup is “probably a human carcinogen”

The WHO’s International Agency for Research on Cancer (IARC) has just published a report from 17 experts from 11 countries who concluded that glyphosate (“Roundup”) is “probably carcinogenic to humans.”

The IARC Working Group found evidence that

Case-control studies of occupational exposure in the USA, Canada, and Sweden reported increased risks for non-Hodgkin lymphoma that persisted after adjustment for other pesticides…In male CD-1 mice, glyphosate induced a positive trend in the incidence of a rare tumour, renal tubule carcinoma. A second study reported a positive trend for haemangiosarcoma in male mice.  Glyphosate increased pancreatic islet-cell adenoma in male rats in two studies. A glyphosate formulation promoted skin tumours in an initiation-promotion study in mice.

Glyphosate has been detected in the blood and urine of agricultural workers, indicating absorption. Soil microbes degrade glyphosate to aminomethylphosphoric acid (AMPA). Blood AMPA detection after poisonings suggests intestinal microbial metabolism in humans. Glyphosate and glyphosate formulations induced DNA and chromosomal damage in mammals, and in human and animal cells in vitro. One study reported increases in blood markers of chromosomal damage (micronuclei) in residents of several communities after spraying of glyphosate formulations. Bacterial mutagenesis tests were negative. Glyphosate, glyphosate formulations, and AMPA induced oxidative stress in rodents and in vitro.

Organophosphate pesticides and herbicides have long been known to be toxic to mammals, but experts have been undecided about whether they cause cancer.

Glyphosate is the herbicide used in conjunction with glyphosate-resistant genetically modified crops.  These are widely planted in the United States (HT means herbicide tolerant).

In addition to causing widespread selection of resistant weeds, glyphosate may also cause cancer.

Add this to the list of scientific reasons for concern about widespread production of GMO crops.  Roundup is used on plants other than GMOs, but GMO corn, cotton, and soybeans use the most.

Note: The FDA has just approved new varieties of GMO apples and potatoes.  These do not use Roundup.

Next: watch Monsanto, the maker of Roundup, attempt to cast doubt on IARC’s scientific judgment.

Addition, March 22:  As an example of the level of the general discussion of GMOs and glyphosate, see this short video clip from French TV (in English) with Patrick Moore.  Mr. Moore, a former director of Greenpeace, has controversial views on climate change and GMOs.

Additions, March 23:

DTN/The Progressive Farmer quotes a Biotechnology Industry Organization representative as pointing out that IARC took the Séralini study seriously, immediately casting doubt on the quality of its literature review (but I can’t find any mention of this study in the IARC report).

Center for Science in the Public Interest urges the EPA to take this seriously.

Consumer Reports is concerned about the vast amounts of glyphosate used and thinks the government should monitor it.

Sep 20 2012

What to make of the scary GMO study?

I am a strong supporter of labeling GMO foods.  Consumers have the right to know.

That’s enough of a reason to support California’s Prop. 37.  There is no need to muddy the waters with difficult-to-interpret science.

My e-mail inbox was flooded with messages yesterday about the new long-term rat study reporting that both GMO corn and Roundup (glyphosate herbicide) increase mammary tumors in mice.

The study, led by Gilles-Eric Séralini, concludes:

The results of the study presented here clearly demonstrate that lower levels of complete agricultural glyphosate herbicide formulations, at concentrations well below officially set safety limits, induce severe hormone-dependent mammary, hepatic and kidney disturbances… the significant biochemical disturbances and physiological failures documented in this work confirm the pathological effects of these GMO and R treatments in both sexes.

These results are so graphically shocking (see the paper’s photographs), and so discrepant from previous studies (see recent review in the same journal), that they bring out my skeptical tendencies.  (Note: Although Séralini is apparently a well known opponent of GMOs, his study—and that of the review—were funded by government or other independent agencies.)

For one thing, the study is weirdly complicated.  To its credit, it went on for two years (much longer than the typical 90 days for these kinds of studies).

But it involves ten separate groups of 20 mice each (10 males and 10 females) fed diets containing GMO (Roundup-resistant) corn, grown with Roundup or not, or fed control diets (non-GMO corn) with or without Roundup added to their drinking water at three different levels.

I needed a Table to keep this straight.

CONTROL AND TREATMENT GROUPS

GROUP %CORNIN DIET CORN TREATEDWITH ROUNDUPHERBICIDE GIVEN ROUNDUPTO DRINK
Non-GMO Control 33% No
GMO Corn 11% No
GMO Corn 22% No
GMO Corn 33% No
GMO Corn 11% Yes
GMO Corn 22% Yes
GMO Corn 33% Yes
Non-GMO Corn 33% No 0.1 ppb (level in tap water).
Non-GMO Corn 33% No 0.09% (level contaminating feed)
Non-GMO Corn 33% No 0.5% (half the level used in agriculture)

 

Complicated studies require careful interpretation.  Here are the main tumor results.

LINES: The dotted line is the control.  The three corn doses (11%, 22%, 33%) correspond to thin, medium and bold lines, respectively.

BARS: 0 = Control.  R = Roundup.  A, B, and C correspond to the three levels of Roundup in drinking water.

 

Besides complications, the study raises several issues:

  • Incomplete data: the authors state that “All data cannot be shown in one report and the most relevant are described here.”  I’d like to know more about what the control rats ate and whether there were differences in the amounts of diets consumed, for example.
  • Lack of dose response: the authors explain that 11% did as much harm as 33% as a threshold effect.  This requires further study to verify.
  • Statistical significance: The paper doesn’t report confidence intervals for the tumor data (the bars don’t look all that different to me).

The California Prop. 37 proponents (and I’m totally with them) already have a strong “right to know” argument.  They don’t need to be distracted by the kinds of scientific arguments that are already raging about this study (see, for example, the British Science Media Centre’s collection of criticisms).

For more information about the study:

The British Sustainable Food Trust has a website devoted to this study.

Tim Carman wrote about it in the Washington Post (I’m quoted)

Andrew Pollack has a sensible piece in the New York Times

France calls for a ban on GM foods

Additional clarification: I very much favor research on this difficult question.   There are enough questions about this study to suggest the need for repeating it, or something like it, under carefully controlled conditions.