by Marion Nestle
Feb 18 2016

The collection continues: 5 more funded studies with results favoring the sponsor. The score: 130/12. Correction: 129/12.

Correction: February 24.  A reader points out that one of the studies posted here had already been posted on January 27  as an industry-negative.  Apologies.  Consider it deleted and change the count.

Yesterday’s post was about a study funded by Disney.  It brought the number of studies funded by companies with results favorable to the company to 125 since last March.  I’ve only found 12 with unfavorable results.  Today’s five raise the count to 130/12.

The association between dietary saturated fatty acids and ischemic heart disease depends on the type and source of fatty acid in the European Prospective Investigation into Cancer and Nutrition–Netherlands cohortJaike Praagman, Joline WJ Beulens, Marjan Alssema, Peter L Zock, Anne J Wanders, Ivonne Sluijs, and Yvonne T van der Schouw. Am J Clin Nutr 2016; 103:356-365 doi:10.3945/ajcn.115.122671.  I posted this study as industry-negative on January 27; it is listed here in error.  

Dietary plant stanol ester consumption improves immune function in asthma patients: results of a randomized, double-blind clinical trial.  Florence Brüll, Els De Smet, Ronald P Mensink, Anita Vreugdenhil, Anja Kerksiek, Dieter Lütjohann, Geertjan Wesseling, and Jogchum Plat. Am J Clin Nutr 2016; 103:444-453 doi:10.3945/ajcn.115.117531

  • Conclusion: To the best of our knowledge, we are among the first authors to show that plant stanol ester consumption improves the immune function in vivo in asthma patients
  • Supported by RAISIO Nutrition LTD. Test products for the study were provided by RAISIO Nutrition LTD…RAISIO Nutrition LTD is a Finnish food company that is involved in life sciences and sells, among other products, the Benecol brand. RAISIO Nutrition LTD had no influence in the setup of the study or the interpretation of the results. None of the authors reported a conflict of interest related to the study.

Low Calorie Beverage Consumption Is Associated with Energy and Nutrient Intakes and Diet Quality in British Adults.  Sigrid A. Gibson, GrahamW. Horgan, Lucy E. Francis, Amelia A. Gibson and Alison M. Stephen.  Nutrients 2016, 8(1), 9; doi:10.3390/nu8010009

  • Conclusion: Results indicate that NC and LCB consumers tend to have higher quality diets compared with SSB or BB consumers and do not compensate for sugar or energy deficits by consuming more sugary foods.
  • Conflicts of Interest: S.G. is director of Sig-Nurture Ltd, an independent consultancy, which has received research funding from food and beverage and ingredient companies, not-for-profit organisations and trade bodies. None of the other authors had a conflict of interest. The sponsors had no role in the design, analysis or interpretation of the study, or in the preparation of the manuscript

Dietary Milk-Fat-Globule Membrane Affects Resistance to Diarrheagenic Escherichia coli in Healthy Adults in a Randomized, Placebo-Controlled, Double-Blind StudySandra J Ten Bruggencate3,*, Pernille D Frederiksen4, Simon M Pedersen5, Esther G Floris-Vollenbroek3, Elly Lucas-van de Bos3, Els van Hoffen3, and Peter L Wejse5.  J. Nutr. February 1, 2016  vol. 146 no. 2 249-255

  • Conclusion: The present diarrheagenic E. coli challenge trial conducted in healthy adults indicates that a milk concentrate rich in natural, bioactive phospho- and sphingolipids from the MFGM may improve in vivo resistance to diarrheagenic E. coli.
  • Author disclosures: SJ Ten Bruggencate, EG Floris-Vollenbroek, E Lucas-van de Bos, and E van Hoffen, no conflicts of interest. PD Frederiksen is an employee of Arla Foods Ingredients Group P/S (AFI, Denmark), which produces and markets Lacprodan MFGM-10, Lacprodan PL-20, and Capolac MM 0525 BG. SM Pedersen and PL Wejse are employees of Arla Foods amba (Denmark). The sponsor was involved in the writing of the manuscript.
  • Comment:  This is the first time I’ve seen a disclosure of the sponsor’s involvement in the writing of a manuscript.  High marks to the Journal of Nutrition for insisting on this.

A 9-mo randomized clinical trial comparing fat-substituted and fat-reduced diets in healthy obese men: the Ole Study.  George A Bray, Jennifer C Lovejoy, Marlene Most-Windhauser, Steven R Smith, Julia Volaufova, Yvonne Denkins, Lilian de Jonge, Jennifer Rood, Michael Lefevre, Alison L Eldridge, and John C Peters.   Am J Clin Nutr 2002;76: 928–34.

  • Conclusion: Replacement of dietary fat with olestra reduces body weight and total body fat when compared with a 25%-fat diet or a control diet containing 33% fat.
  • Supported in part by…the USDA and by the Procter & Gamble Co, Cincinnati.
  • https://drive.google.com/file/d/0B0i-7BgAEplYQ1hFSHJydF9tcjQ/view?usp=sharing . Jeffrey talks quite extensively about the dangers of antibiotic resistance going from GM crop into your gut bacteria. I did not want to just repeat the so called “industry talking points”, ie the knee jerk reactions of any biologist. My knee jerk reaction would tell me that the version of antibiotic resistance gene which is inserted in plants with the plant regulatory elements will not work properly in gut bacteria. At the same time our environment provides abundant sources of antibiotic resistance genes with the proper regulatory elements which are much easier acquired by bacteria. But since I am curious by nature, I thought it might be pretty easy to test it whether it is just the textbook answer or whether it is so called truth. So I did the following experiment – I took a petri dish with Kanamycin (that is the most commonly used antibiotic in plant science since 1985) and spread there a bacterial culture with bacterial kanamycin resitence gene, bacterial culture with plant kanamycin resistence gene (under 35S and nos-terminator control, the same gene is probably in 90% of transgenic plants with kanamycin resistence), and printed there my thumb after touching soil, doorhandle and after washing my hands with liberal amounts of soap. The bacteria with plant KanR gene as well as clean hands turned out to be negative while dirty hands, soil, door knob and positive controls were positive- there were some colonies of Kanamycin resistant bacteria growing. So the conclusion is the kanamycin resistance gene with plant control elements is not working properly in bacteria even that the bacteria in my experiment had about 200 copies of that gene per cell. There is still a possibility that the bacteria would acquire just the exact fragment of the gene without the plant regulatory elements, but the likelihood of that happening is again significantly lower. At the same time eating food that has been in contact with soil with dirty hands provides abundant sources of the correct resistance genes. Not to mention that newer and herbicide tolerant crops do not contain antibiotic resistance genes at all.

  • Also I would like to point out how our personal biases influence our judgments of all these posted videos. You are convinced that Robert lost the debate to Steven Druker and that Jeffrey (by coincidence both from the same Maharishi cult) destroyed absent opponent Neil deGrasse. My feeling from those videos were exactly the opposite. I am not trying to say that my opinion is better than yours or vice versa, just that people have different perspectives and that influences how they evaluate and weight arguments.

  • JW Ogden

    So you need to first judge what the expected rate of confirming studies should be and I doubt that it is 50%.

  • TZ

    You think an experiment you supposedly completed with the results you had predetermined means ANYTHING to me? NO! Sorry. LOL Oh, and not a chance I will be opening your Google drive link!

    What is interesting is the actual health experts disagree with you. For example, The British Medical, Associations says “There should be a ban on the use of antibiotic resistance marker genes in GM food, as the risk to human health from antibiotic resistance developing in micro-organisms is one of the major public health threats that will be faced in the 21st Century. The risk that antibiotic resistance may be passed on to bacteria affecting human beings, through marker genes in the food chain, is one that cannot at present be ruled out.”

    For you to claim “our environment provides abundant sources of antibiotic resistance genes ” is simply a strawman. It is equivalent to saying lightning might kill us, therefore let’s not be concerned about regulating who installs electricity in our homes, etc. It is also a strawman to claim, “newer and herbicide tolerant crops do not contain antibiotic resistance genes at all.” So maybe in the future ARMs will not be used, but since there are still GE crops with ARMs on the market it is still a risk.

    Hmmmm, and you people say Jeffrey Smith is the quack? Lol All you could pull out of EVERYTHING he said has to do with antibiotic resistance genes, which BTW you did not prove to me or anyone else with your so called experiment, is not a real threat to human and animal health.

  • TZ

    Okay, first, you insult your own intelligence by even trying to say anyone thought Wager won that debate. He acted like a two year on a sugar high, confused and enraged. He had zero control of himself or even his own thoughts. He needs some medical intervention.

    See this is another reason why the anti GMO movement is going to continue to GROW! You are disingenuous. You know Wager LOST that is why NOT ONE troll has posted the link to that debate! Not one! Nor has one troll responded to Jeffrey’s challenge. Pathetic.