This is a talk on Zoom about my new book, Let’s Ask Marion.
6:30 at the Jewish Community Center. Information and registration (required for Zoom link) here.
I’m having trouble keeping up with industry-sponsored nutrition research so will use this week’s posts to catch up. I’ll start with this one.
Nutrition journals often publish supplements on specific themes that are paid for by outside parties, food industry groups among them. The February 2016 issue of the Journal of Nutrition contains a supplement with the papers from the 2014 International Garlic Symposium: “Role of Garlic in Cardiovascular Disease Prevention, Metabolic Syndrome, and Immunology.”
To distinguish supplement papers from peer-reviewed journal articles, citations give page numbers with the letter S. The Journal of Nutrition’s exceptionally clear policy on supplement publications explains that organizers are expected to pay page charges of $75 per article and $300 per published page plus additional editorial costs as needed. It views supplements as paid advertisements and requires full disclosure of funding sources.
Here’s the disclosure for the garlic supplement.
The symposium was sponsored by the University of California, Los Angeles School of Medicine and the University of Florida and co-sponsored by the American Botanical Council; the American Herbal Products Association; the ASN [American Society for Nutrition]; the Japanese Society for Food Factors; the Japan Society for Bioscience, Biotechnology, and Agrochemistry; the Japan Society of Nutrition and Food Science; and the Natural Products Association. The symposium was supported by Agencias Motta S.A.; Bionam; Eco-Nutraceuticos; Healthy U 2000 Ltd.; Magna; Mannavita Bvba; MaxiPharma; Medica Nord A.S.; Nature’s Farm Pte. Ltd.; Nature Valley W.L.L.; Organic Health Ltd.; Oy Valioravinto Ab; Purity Life Health Products L.P.; PT Nutriprima Jayasakti; Vitaco Health Ltd.; Vitae Natural Nutrition; Sanofi Consumer Health Care; Wakunaga Pharmaceutical Co., Ltd.; and Wakunaga of America Co., Ltd. The Chair of the conference and Scientific Program Coordinator for the supplement publication was Matthew J Budoff, Harbor-UCLA Medical Center, Torrance, CA. Scientific Program Coordinator disclosures: MJ Budoff has been awarded research grants from Wakunaga of America Co., Ltd., and received an honorarium for serving as Chair of the conference. Vice-Chair and Supplement Coordinator for the supplement publication was Susan S Percival, University of Florida, Gainesville, FL. Supplement Coordinator disclosures: SS Percival has been awarded research grants from Wakunaga of America Co., Ltd., and received an honorarium for serving as Vice-Chair of the conference. Publication costs for this supplement were defrayed in part by the payment of page charges. This publication must therefore be hereby marked “advertisement” in accordance with 18 USC section 1734 solely to indicate this fact. The opinions expressed in this publication are those of the authors and are not attributable to the sponsors or the publisher, Editor, or Editorial Board of The Journal of Nutrition [my emphasis].
Comment on scoring: Because they were presented at a symposium sponsored by food and supplement companies, all papers raise questions about industry sponsorship. That is why the Journal requires every paper in the supplement to repeat this funding disclosure in its entirety.
But for this particular symposium, some of the papers report additional funding by Wakunaga of America, a company that, no surprise, manufactures garlic supplements.
All of the papers produced results useful to the sponsor. Some of them, however, were independently funded and the authors report no links to the sponsor other than having given a talk at the meeting. They did not disclose who paid for travel and hotels and without any way to check, I must assume that they paid their own expenses to the meeting in San Diego. For the purposes of scoring, I’m not counting them as industry-funded, even though their presence at the symposium made it seem more scientifically credible.
Garlic Lowers Blood Pressure in Hypertensive Individuals, Regulates Serum Cholesterol, and Stimulates Immunity: An Updated Meta-analysis and Review. Karin Ried. J Nutr. 2016; 146:389S-396S doi:10.3945/jn.114.202192.
Chemical Assignment of Structural Isomers of Sulfur-Containing Metabolites in Garlic by Liquid Chromatography−Fourier Transform Ion Cyclotron Resonance−Mass Spectrometry. Ryo Nakabayashi, Yuji Sawada, Morihiro Aoyagi, Yutaka Yamada, Masami Yokota Hirai, Tetsuya Sakurai, Takahiro Kamoi, Daryl D Rowan, and Kazuki Saito. J. Nutr. 2016; 146:397S-402S doi:10.3945/jn.114.202317.
Garlic-Derived Organic Polysulfides and Myocardial Protection. Jessica M Bradley, Chelsea L Organ, and David J Lefer. J. Nutr. 2016; 146:403S-409S doi:10.3945/jn.114.208066.
Aged Garlic Extract Inhibits Human Platelet Aggregation by Altering Intracellular Signaling and Platelet Shape Change. Khalid Rahman, Gordon M Lowe, and Sarah Smith. J. Nutr. 2016; 146:410S-415S doi:10.3945/jn.114.202408
Garlic and Heart Disease. Ravi Varshney and Matthew J Budoff. J. Nutr. 2016; 146:416S-421S doi:10.3945/jn.114.202333
The Role of Adiponectin in Cardiometabolic Diseases: Effects of Nutritional Interventions. Patricio Lopez-Jaramillo. J. Nutr. 2016; 146:422S-426S doi:10.3945/jn.114.202432
Aged Garlic Extract Reduces Low Attenuation Plaque in Coronary Arteries of Patients with Metabolic Syndrome in a Prospective Randomized Double-Blind Study. Suguru Matsumoto, Rine Nakanishi, Dong Li, Anas Alani, Panteha Rezaeian, Sach Prabhu, Jeby Abraham, Michael A Fahmy, Christopher Dailing, Ferdinand Flores, Sajad Hamal, Alexander Broersen, Pieter H Kitslaar, and Matthew J Budoff. J. Nutr. 2016; 146:427S-432S doi:10.3945/jn.114.202424
Aged Garlic Extract Modifies Human Immunity. Susan S Percival. J. Nutr. 2016; 146:433S-436S doi:10.3945/jn.115.210427
Bioavailability of Alfrutamide and Caffedymine and Their P-Selectin Suppression and Platelet-Leukocyte Aggregation Mechanisms in Mice. Jae B Park. J. Nutr. 2016; 146:437S-443S doi:10.3945/jn.114.202473
Garlic Influences Gene Expression In Vivo and In Vitro. Craig S Charron, Harry D Dawson, and Janet A Novotny. J. Nutr. 2016; 146:444S-449S doi:10.3945/jn.114.202481
Development of an Analytic Method for Sulfur Compounds in Aged Garlic Extract with the Use of a Postcolumn High Performance Liquid Chromatography Method with Sulfur-Specific Detection. Toshiaki Matsutomo and Yukihiro Kodera. J. Nutr. 2016; 146:450S-455S doi:10.3945/jn.114.208520
Pharmacokinetics of S-Allyl-L-cysteine in Rats Is Characterized by High Oral Absorption and Extensive Renal Reabsorption. Hirotaka Amano, Daichi Kazamori, and Kenji Itoh. J. Nutr. 2016; 146:456S-459S doi:10.3945/jn.114.201749
Aged Garlic Extract Suppresses the Development of Atherosclerosis in Apolipoprotein E–Knockout Mice. Naoaki Morihara, Atsuko Hino, Takako Yamaguchi, and Jun-ichiro Suzuki. J. Nutr. 2016; 146:460S-463S doi:10.3945/jn.114.206953
This makes 8 industry-positives from this journal supplement.
But let me add one more on this topic, sent by a reader:
The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: the AGE at Heart trial. Karin Ried Nikolaj Travica, Avni Sali. Integrated Blood Pressure Control, 27 January 2016.
This brings the score since last March to 119 industry-positives/11 industry-negatives.