I’m on a panel for the NYAS’s conference on Conflicts of Interest in Healthcare: Opportunities for Self-Reflection and Action, June 24-25. Location: 7 World Trade Center. 250 Greenwich St, 40th Floor. Information and registration are here. My panel is on the 25th at 10:45 a.m. , Session VI: Hot topic discussion: getting to the truth in nutrition science. Other panelists are Mona Calvo fro Penn State, Mehmood Khan from Life Biosciences, and Linda Van Horn from Northwestern. Moderator is Julia Belluz from Vox.
Do artificial sweeteners cause–not cure–glucose intolerance?
The big nutrition scare last week was the study in Nature finding that in mice and, maybe, humans, artificial sweeteners mess up the microbiome and make some people even more intolerant of glucose.
The authors conclude that their results call for a reassessment of massive use of artificial sweeteners.
The study is complicated and difficult to read but the Wall Street Journal has a nice summary. It explains why the study is getting so much attention:
The new Nature study marks a significant advance because it brings together two separate areas of research—the role of sweeteners in raising blood sugar levels, and the complex workings of the vast colonies of bacteria that inhabit the gut. Individuals can have differing bacterial colonies in their gut, meaning people respond differently to what they consume.
The study involved several experiments. These found:
- Mice fed saccharin, sucralose, or aspartame had significantly higher blood-glucose levels than mice whose diet included sugar, or just water.
- Mice with sterilized digestive tracts, who were given bacterial transplants from artificial-sweetener-fed mice, displayed higher blood sugar levels than those receiving bacterial transplants from sugar-fed mice.
- People who typically use artificial sweeteners have different kinds of bacteria in their intestines than those who do not. They also are more glucose intolerant.
- Seven volunteers fed artificial sweeteners for four days displayed higher blood-sugar levels as well as altered populations of bacteria in their gut.
The Wall Street Journal quotes the Calorie Control Council (the trade association of makers of artificial sweeteners). The CCC said:
The results from the mouse experiments may not apply to humans, while the human experiments had a small sample size. It said further research was needed.
Despite my lack of enthusiasm for artificial sweeteners, I think the Calorie Control Council has a point.
The excellent report by Kenneth Chang in the New York Times explains why.
At present, the scientists cannot explain how the sweeteners affect the bacteria or why the three different molecules of saccharin, aspartame and sucralose result in similar changes in the glucose metabolism.
Chang ends with this:
Dr. Frank Hu, a professor of nutrition and immunology at the Harvard School of Public Health who did not take part in the study, called it interesting but far from conclusive and added that given the number of participants, “I think the validity of the human study is questionable.”
Here’s why I’m not fond of artificial sweeteners:
- They taste bad (to me)
- They have no demonstrated effectiveness in helping people lose or maintain weight.
- They are artificial, and violate my rule to “never eat anything artificial.”
Do they mess up the microbiome and cause glucose intolerance, insulin resistance, and metabolic syndrome?
That would be fascinating, but I’m reserving judgment pending further research.
In the meantime, I’ll take sugar—in moderation, of course.