by Marion Nestle

Currently browsing posts about: Conflicts-of-interest

Mar 4 2024

How the food industry exerts influence I: food and nutrition professionals (potato industry)

Lately, I have been asked repeatedly to explain just how the food industry exerts influence to protect and promote product sales.  This week’s posts address that question, starting with the usual Monday industry-funded study of the week, in this case an opinion piece sponsored by the potato industry.

Potato trade associations work hard to overcome concerns about this food’s rapidly absorbable starch content.

I received an email from the Alliance for Potato Research & Education telling me that if I don’t eat potatoes, I might become nutritionally deficient.

New publication alert: swapping out starchy vegetables may lead to unintended nutrition consequences.

A new perspective paper published in Frontiers in Nutrition underscores starchy vegetables are more than just carbs – they’re a vital vehicle for essential nutrients. Yet, as confusion around “good versus bad carbs” persists among consumers, there is a risk of starchy vegetable avoidance in favor of other carbohydrate foods perceived as equally or more nutritious – or even carbohydrate avoidance all together.

The press release cited a paper with this conclusion:

Replacing starchy vegetables with grain-based alternatives, including whole-grain foods, for one day led to a 21% decrease in potassium, a 17% decrease in vitamin B6, an 11% drop in vitamin C and a 10% reduction in fiber.

This called for a look at the actual paper.

The paper: Carbohydrate confusion and dietary patterns: unintended public health consequences of “food swapping.”   Ayoob, K.  Front. Nutr., 28 September 2023. Volume 10 – 2023 |

Rationale: “Nutrient-dense dietary patterns include both grain foods and starchy vegetables. These food groups are currently considered separately [by the Dietary Guidelines for Americana], and they must remain separate to ensure people are encouraged to consume complementary nutrients from each of these food groups.”

Conclusion: “Using complex carbohydrate foods, specifically starchy vegetables (e.g., potatoes) and grains, interchangeably is at best, not a useful strategy, but at worst, may increase the risk of micronutrient inadequacy and/or dietary imbalances.”

Funding: “The author(s) declare financial support was received for the research, authorship, and/or publication of this article. Funding for this perspective was provided by Potatoes USA.”

Conflict of interest: “This study received funding from Potatoes USA. The funder had the following involvement with the study: composition and data analysis of the menu modeling. KA was compensated by Potatoes USA for preparation and revision of the manuscript.  The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.”

Comment: I like potatoes, think they have nutritional value (especially when baked rather than fried), and do not view them as poison.  But: this paper is an opinion piece commissioned, developed, and paid for by a potato trade association.  And sent to me in a press release.

Feb 26 2024

Industry-funded studies of the week: meat

Every now and then, someone sends me something about industry-funded research that does my work for me.  Here is an example.

I received this e-mailed message from John Andrews (reproduced with permission).

I’m sure others will have shared this with you, but as someone primed by reading your work to dig into authors’ backgrounds, I couldn’t help but notice some aspects of a new special issue of Animal Frontiers on ‘The Societal Role of Meat’ (link) that you might be interested to see. There are 36 authors across the special issue, but to highlight just a handful:

  • Peer Ederer, guest editor and co-author of the introduction article, has his affiliation listed as ‘GOALScience at Global Food And Agriculture Network’ in Switzerland. However, the website of GOALScience describes themselves as an initiative of the ‘Global Food and Agribusiness Network’ (my italics), and describes itself as a commercial entity that operates as a “service to the global livestock stakeholder community” (link). The paper Ederer et al in the special issue (link) has a conflict of interest statement: “None declared.”
  • Thompson et al (link) lists among its authors Jason Rowntree. Rowntree is described in his biography as having worked with the Savory Institute to develop its ‘Ecological Outcome Verification’ scheme for livestock farming. Rowntree’s biography on his university page describes him as an ‘advisor and educator’ to the Savory Institute. Savory’s website indicates that Rowntree’s university is what’s called a ‘Savory Hub’, and that Rowntree has at some point been ‘Hub leader’ (link). Rowntree is also co-lead on a $19mn research project in which Savory is a partner (link). The conflicts of interest statement for the article: “None declared”.
  • Rod Polkinghorne, co-author of the perspective article (link), describes himself on his LinkedIn as “actively involved with the beef industry”. In fairness, his biography in the special issue does not disguise this, and the perspective article does not contain a conflict of interest statement of any kind.

I don’t want to suggest that this is particularly surprising in a journal that has a longstanding partnership with the American Meat Science Association, which partnership is not at all hidden (e.g. the journal’s ‘about’ page and Dilger, 2020). But the special issue is noteworthy as the claimed evidence base to support the ‘Dublin Declaration’ on the ‘societal role of livestock’, reported in the press in classic fashion (a Daily Telegraph headline in the UK reads ‘Meat is crucial for human health, scientists warn’), and actively being used as part of the current lobbying battles around EU environmental legislation (see e.g. here).

Perhaps I just don’t understand the subtleties of the term ‘conflict of interest’ well enough…

Comment: Thanks for all this.  Yes, industry connections like these pose conflicts.  These authors—and the journal in which they publish—have financial ties to an industry with an economic stake in the results of studies and the opinions of authors.

Indeed, these particular conflicts of interest are so evident that The Guardian did an article about them:  Revealed: The livestock consultants behind the Dublin Declaration of Scientists.

While I’m at it, let me toss in one more as an example of how meat industry funding works.

The study: Higher muscle protein synthesis rates following ingestion of an omnivorous meal compared with an isocaloric and isonitrogenous vegan meal in healthy, older adults (thanks to Charles Platkin for sending this one).

Conclusion: “Ingestion of a whole-food omnivorous meal containing beef results in greater postprandial muscle protein synthesis rates when compared with the ingestion of an isonitrogenous whole-food vegan meal in healthy, older adults.”

Funding: “This study was funded in part by The Beef Checkoff, Denver, USA, and Vion Food Group, Boxtel, The Netherlands.”

When I see a title like this, I can guess who paid for the study.  Not good.

Feb 19 2024

Industry-sponsored study of the week: a menstruation supplement

The study:  Lactobacillus paragasseri OLL2809 Improves Premenstrual Psychological Symptoms in Healthy Women: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients. 2023; 15(23):4985. https://doi.org/10.3390/nu15234985

Methods: “This study employed a randomized, placebo-controlled, double-blind, parallel-group design to assess the efficacy of continuous ingestion of OLL2809 [the supplement] for managing menstrual symptoms in healthy women.”

Conclusion: “This study suggests that the consumption of OLL2809 over three menstrual cycles in healthy women can alleviate premenstrual ‘decline in activity’ and ‘irritability’, thereby indicating the potential of OLL2809 to enhance women’s QOL [Quality of Life].

Conflicts of Interest:  All authors are employees of Meiji Co., Ltd. The company funded this research. All authors are the inventors of pending patent (Japanese Patent Application No. 2023-182470).

Comment: The supplement is a bacterial probiotic.  The authors are employed by its maker and hold a patent for it, which they fully disclose.  Just as a reminder, industry-funded studies tend to come out with results favoring the sponsor’s interest, as is certainly the case here.

I need to say something about the journal, Nutrients, since many of the studies I post on industry-funded Mondays appear in that journal.  It charges authors €2900 (about $3300) to publish their articles.  It’s an open-access journal, so all authors have to pay to publish their articles.  More rigorous journals do not usually require page charges from authors unless they want open access.  Nutrients gives me the impression of pay to play.

Feb 12 2024

Industry-funded study of the week: Et tu saffron?

I learned about this one from NutraIngredients-Europe:

The ‘promising’ role of saffron in stress resilience:  New research conducted in partnership with botanical product manufacturer Pharmactive reveals that its standardized saffron extract Affron was able to normalise HPA [hypothalamic-pituitary-adrenal] axis dysregulation following chronic mild stress stimulation in a rat model…. Read more

I thought this was worth a closer look and went right to the paper.

Effects of Saffron Extract (Affron®) with 100 mg/kg and 200 mg/kg on Hypothalamic–Pituitary–Adrenal Axis and Stress Resilience in Chronic Mild Stress-Induced Depression in Wistar Rats. Nutrients 202315(23), 4855; https://doi.org/10.3390/nu15234855

Conclusion: These findings elucidate AFN’s [Affron®] role in stress mitigation, affirm its health benefits, validate its potential as a treatment for stress-related symptoms, confirm its physiological effectiveness, and emphasize its therapeutic promise.

Guess who generated and conducted this study.

Conflict of interest statement: For commercial affiliations, J.K. and S.Y. were employed by the company iCONNECTOME Co., Ltd., which had the roles of curation, formal analysis, and visualization in this study; S.-S.Y. was employed by the company iCONNECTOME Co.,Ltd., which had the roles of conceptualization, funding acquisition, investigation, supervision, review and editing in this study; M.-Y.K. and J.S. were employed by the company Hyundai Bioland Co.,Ltd., which had the roles of methodology and/or writing original draft in this study; M.I.M.-V. was employed by the company Pharmactive Biotech S.L.U., which had the role of investigation in this study. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

In case you wondered, Pharmactive Biotech makes Affron.  The other enterprises do the studies.

Who paid for this?

Funding: This research was funded by Hyundai Bioland Co., Ltd., grant number IC22_02, and Soonchunhyang University Research Fund. Hyundai Bioland Co., Ltd. had the following involvement with the study: participating in the research Investigation, and paid all costs for editing and publishing the Paper. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication.

Comment: Huh?  I often suspect that the statement “the funder was not involved….” may not accurately represent the funder’s involvement (to put the matter politely).  In this case,  the role of Hyundai Bioland is self-contradictory.  Its employee-authors say they determined the study’s methods and/or wrote the paper, and the funder says it participated in the research but had no involvement in the study design, etc.  This is confusing, if not contradictory.

I do have to say something about marketing saffron as a superfood.  Saffron consists of the stigmas of crocus flowers, and these are hugely expensive.  Walmart is selling 2 grams for $42.

The Wikipedia entry iexplains why.

The high retail value of saffron is maintained on world markets because of labour-intensive harvesting methods, which require some 440,000 hand-picked saffron stigmas per kilogram…150,000 crocus flowers per kilogram…Forty hours of labour are needed to pick 150,000 flowers…One freshly picked crocus flower yields on average 30 mg of fresh saffron or 7 mg dried; roughly 150 flowers yield 1 g (132 oz) of dry saffron threads.

Once again, we have here an industry-funded marketing study pretending to be science.  But really, saffron?   OK, an extract that maybe can be synthesized, but still.  There have to be easier and less expensive ways to reduce stress and depression in rats.

Oh.  And in case you were wondering how scientists determine whether rats are depressed?

Our previous animal behavioral assays assessing anxiety and depression, including the elevated plus maze, forced swim, and sucrose preference tests, have revealed that AFN-treated animals (200 mg/kg) exhibit behaviors indicative of anhedonia and depression mitigation [27]. For example, increased consumption of sugar solutions and improved specific escape responses have been observed in forced swim tests.

Ref 27 is: Orio, L.; Alen, F.; Ballesta, A.; Martin, R.; Gomez de Heras, R. Antianhedonic and Antidepressant Effects of Affron®, a Standardized Saffron (Crocus sativus L.) Extract. Molecules 202025, 3207. [Google Scholar]

Jan 29 2024

Industry-conflicted opinion of the week: Sugar, if you can believe it

I like sweet foods as much as anyone (maybe more), but I do try to keep sugar intake within reasonable limits.

For one thing, sugars have no nutritional value beyond calories (which hardly anyone needs more of).  For another, it encourages overeating whatever foods in comes with, many of them ultra-processed.

Thus, I cannot understand why my nutrition colleagues would do anything to imply that eating more sugar is OK.

But, thanks to Ricardo Salvador at the Union of Concerned Scientists who forwarded the study to me, we here have: Risk assessment of nutrients: There must be a threshold for their effects.

Its authors argue that because no firm threshold has been established for harm from excessive sugar intake, guidance to keep sugars “as low as possible in the context of a nutritionally adequate diet” is inappropriate.

The most appropriate interpretation from the vast amount of data is that currently no definitive conclusion can be drawn on the tolerable upper intake level for dietary sugars. Therefore, EFSA’s [European Food Safety Authority’s] own guidance would lead to the conclusion that the available data do not allow the setting of an upper limit for added sugars and hence, that more robust data are required to identify the threshold value for intake of sugars.

Sigh.  Who paid for this?

Funding:Cosun Nutrition Center (Hilversum, The Netherlands) provided financial support for some of the cost for the preparation of this paper. This support was unrestricted, and Cosun Nutrition Center had no influence on or input to the content of this paper” [yeah, right].

And what, pray tell, is the Cosun Nutrition Center?

The Cosun Nutrition Center conducts research and acquires scientific information on plant-based foods in relation to health and sustainability…The Cosun Nutrition Center is funded by Royal Cosun.

Sounds legit.  But what is Royal Cosum?

Founded 125 years ago, Royal Cosun has developed into a leading international agricultural cooperative with more than 8,100 sugar beet growers.

Sugar beet growers?  Oh.

I won’t bother to list the authors’ conflicts of interest, except to assure you that some include affiliations with sugar companies.

Conflicted?  Absolutely.

Caveat lector.

Jan 22 2024

Industry-funded studies of the week: the Beef Checkoff in action

Let’s do two at once—studies funded by gthe beef industry.

I.  BEEF AND MUSCLES

I learned about this one from a headline in Food Navigator — Europe’s daily newsletter: Muscle protein synthesis more successful with beef than plant-based protein in older people, study finds

One look at the headline and I wanted to know: Who paid for this?

The study:  Higher Muscle Protein Synthesis Rates Following Ingestion of an Omnivorous Meal Compared with an Isocaloric and Isonitrogenous Vegan Meal in Healthy, Older Adults.  Journal of Nutrition.  2023. DOI:https://doi.org/10.1016/j.tjnut.2023.11.004.

Purpose: Plant-derived proteins are considered to have fewer anabolic properties when compared with animal-derived proteins…So far, no study has compared the anabolic response following ingestion of an omnivorous compared with a vegan meal.

Methods: In a randomized, counter-balanced, cross-over design, 16 older (65–85 y) adults (8 males, 8 females) underwent 2 test days. On one day, participants consumed a whole-food omnivorous meal containing beef as the primary source of protein (0.45 g protein/kg body mass; MEAT). On the other day, participants consumed an isonitrogenous and isocaloric whole-food vegan meal (PLANT).

Results: MEAT increased plasma essential amino acid concentrations more than PLANT over the 6-h postprandial period (incremental area under curve 87 ± 37 compared with 38 ± 54 mmol·6 h/L, respectively; P-interaction < 0.01). Ingestion of MEAT resulted in ∼47% higher postprandial muscle protein synthesis rates when compared with the ingestion of PLANT (0.052 ± 0.023 and 0.035 ± 0.021 %/h, respectively; paired-samples t test: P = 0.037).

Conclusions:  Ingestion of a whole-food omnivorous meal containing beef results in greater postprandial muscle protein synthesis rates when compared with the ingestion of an isonitrogenous whole-food vegan meal in healthy, older adults.

And now to answer my question:

  • Conflict of interest:  [two of the authors] received research grants, consulting fees, speaking honoraria, or a combination of these for research on the impact of exercise and nutrition on muscle metabolism. A full overview on research funding is provided at: https://www.maastrichtuniversity.nl/l.vanloon. All other authors report no conflicts of interest.
  • Funding:  This study was funded in part by The Beef Checkoff, Denver, USA, and Vion Food Group, Boxtel, The Netherlands….The funders had no role in data collection and analysis, decision to publish, or preparation of the manuscript.

Comment:  The Beef Checkoff is the USDA-sponsored research-and-marketing program which taxes beef producers and uses the funds to promote beef sales.  Maybe the funder had no role as stated, but the checkoff is unlikely to fund research that is not in its best interest.

The meat industry wants everyone to believe that meat is superior to plants, as food, and eating vegan diets is hazardous to health.  Hence, this research.

Something is seriously wrong when it is this easy to guess who paid for a study from its title alone.

II.  BEEF AND  MENTAL HEALTH

Just when I was ready to post that item, I ran across another one.

The study: Meat consumption & positive mental health: A scoping review. Preventive Medicine Reports. Volume 37, January 2024, 102556.

Highlight: “The majority of studies showed no differences between meat consumers and meat abstainers in positive psychological functioning.”

Results: “Eight of the 13 studies demonstrated no differences between the groups on positive psychological functioning, three studies showed mixed results, and two studies showed that compared to meat abstainers, meat consumers had greater self-esteem, ‘positive mental health’, and ‘meaning in life.'”

Conclusion [a positive spin]: “Although a small minority of studies showed that meat consumers had more positive psychological functioning, no studies suggested that meat abstainers did.”

Funding source: This study was in part funded via an unrestricted research grant from the Beef Checkoff, through the National Cattlemen’s Beef Association. The sponsor of the study had no role in the study design, data collection, data analysis, data interpretation, or writing of the report.

Declaration of competing interest: [The first author] previously received funding from the Beef Checkoff, through the National Cattlemen’s Beef Association.

Comment: This review caught my attention because it found a null result: beef eating has no effect on mental health.  This is unusual for industry-funded studies.  But the article contains a positive spin:  some studies do in fact find benefits of beef eating whereas none find this result from not eating beeef.  Make of this what you will.  I think the Highlight says all you need to know.  Industry funding muddies interpretation of research results.  It’s best to avoid taking it.

Dec 19 2023

Industry-funded study of the week: Quorn

[Note: If you saw this yesterday, ignore.  I made a scheduling error so this post got sent out with yesterday’s.  Apologies.]

A reader in Scotland,  Prof. Lindsay Jaacks, who I was fortunate to meet in Edinburgh last April,  tweeted (X’d?) this and tagged me on it::

A new study funded by @QuornFoods finds health benefits of substituting ‘Mycomeat’ for red & processed meat.
We need independent evidence far from the hands of industry if we are going to transform #FoodSystems.

I looked it up:

The study: Farsi, D.N., Gallegos, J.L., Finnigan, T.J.A. et al. The effects of substituting red and processed meat for mycoprotein on biomarkers of cardiovascular risk in healthy volunteers: an analysis of secondary endpoints from Mycomeat. Eur J Nutr 62, 3349–3359 (2023). https://doi.org/10.1007/s00394-023-03238-1.

  • Purpose:  “Mycoprotein is a relatively novel food source produced from the biomass of Fusarium venenatum. It has previously been shown to improve CVD risk markers in intervention trials when it is compared against total meat. It has not hitherto been assessed specifically for benefits relative to red and processed meat.”
  • Methods:  “We leveraged samples from Mycomeat, an investigator-blind randomised crossover controlled trial in metabolically healthy male adults (n = 20), randomised to consume 240 g/day of red and processed meat for 14 days followed by mycoprotein, or vice versa. Blood biochemical indices were a priori defined secondary endpoints.”
  • Results:  “Mycoprotein consumption led to a 6.74% reduction in total cholesterol (P = 0.02) and 12.3% reduction in LDL cholesterol (P = 0.02) from baseline values…There was a small but significant reduction in waist circumference for mycoprotein relative to meat (− 0.95 ± 0.42 cm, P = 0.04). Following the mycoprotein diet, mean systolic (− 2.41 ± 1.89 mmHg, P = 0.23) and diastolic blood pressure (− 0.80 ± 1.23 mmHg, P = 0.43) were reduced from baseline.”  Urinary potassium was higher, but the study found no difference in triglycerides, urinary sodium, nitrite, or TMAO.
  • Conclusions: “These results confirm potential cardiovascular benefits when displacing red and processed meat with mycoprotein in the diet. Longer trials in higher risk study populations are needed to fully elucidate suggested benefits for blood pressure and body composition.”
  • Conflict of interest:  “This work was part funded by Marlow foods Ltd. TJAF is a consultant to Marlow Foods.”

Comment

Marlow Foods is the parent company of Quorn, mycelium-based products.  Quorn products have been around in the U.S. since 2002.  The Center for Science in the Public Interest has been dubious about these products ever since, arguing that Quorn induces allergic reactions and gastrointestinal distress and should be labeled as such.  It has also filed a class action lawsuit and engaged in other litigation.  CSPI refers to Quorn as “fungus” or “mold.”  Marlow, and other producers of mycelium-based meat substitutes prefer “mushroom.”  Marlow is doing what it can to counter criticism of the safety of theae products.

If you want to try Quorn, be sure to check the ingredient list.  Here’s what’s in QUORN VEGAN MEATLESS SPICY CHIQIN PATTIES:

Mycoprotein (54%), Wheat Flour (Wheat Flour, Calcium Carbonate, Iron, Niacin, Thiamine), Canola Oil, Water, Wheat StarchWheat Gluten, Pea Protein, Potato Protein, Calcium Chloride, Calcium Acetate, Salt, Chilli Flakes, Parsley, Yeast Extract, Onion Powder, Garlic Powder, Pea Fiber, Yeast, Tomato Powder, Spices (Cayenne Pepper, White Pepper), Carrageenan, Sodium Alginate, Rice Flour, Spice Extracts (Black Pepper Extract, Cayenne Extract, Ginger Extract), Paprika Extract (Coloring), Natural Flavor, Sage, Sugar, Leavening (Ammonium Carbonate)., Contains Wheat.

Ultra-processed? absolutely [industrially extracted ingredients; not much real food except wheat; you can’t reproduce this in your home kitchen].

Delicious?  You decide.

Dec 18 2023

Should food companies—and the Gates Foundation—sponsor nutrition conferences? In India?

I saw this posted on X (the site formerl known as Twtter, which I still find to be a useful source of information I would not otherwise know about).

I also saw a post from Joes Spicer, head of Nutrition International, announcing its withdrawal of funding for the conference  because of the food industry sponsors.

And then Tim Schwab, whose book, “The Bill Gates Problem,” I cannot wait to get to, sent this:

In India last week, a minor furor erupted over the Nutrition Society of India’s annual conference being so brazenly sponsored by companies like Coca-Cola.  But Coke is only a “gold” sponsor.  The “platinum” sponsor? The Gates Foundation.

For two decades, Gates has partnered closely with corporate interests—from Coca-Cola to Pfizer—and presented them to the world as humanitarian partners. Because the foundation is such an admired and celebrated charitable body, Gates has had a powerful effect on normalizing, institutionalizing and legitimizing corporate partnerships and conflicts of interest throughout science and policy making.

Food and drug companies love to sponsor nutrition conferences.  What better way to convince influential professional researchers and teachers that your products are good for health and nothing should be said about restricting or regulating them.

The role of the Gates Foundation is much less obvious and much more important because of its money and interntional power.  Schwab’s book promises to address such matters.  I will have more to say about it when I’ve had a chance to read it.

In the meantime, nutriton societies oin the U.S. and India too would be more credible if they avoided taking food industry sponsorship.  If they take Gates Foundation money, it had best come with no strings and no implied endorsements.

If F0undatios were really altruistic, they would provide donations anonymously and not expect a quid pro quo.  When they expect a quid pro quo, it’s best to find out exactly what it is.