Search results: meat drugs

Last week, the USDA and FDA ended their turf battle and announced a joint framework for jointly regulating cell-based meat products.

Congress instructed them to do this in a statement related to the Appropriations Act:

Not later than 60 days after the date of the enactment of this Act, the Secretary of Agriculture and the Commissioner of Food and Drugs shall enter into a formal agreement delineating the responsibilities of the two agencies for the regulation of cell-cultured food products derived from livestock and poultry. Such agreement shall be made public on the USDA and FDA websites within one day of the completion of the agreement.

These products, not yet on the market, are made from animal cells grown in tissue culture; no animals are killed in the process.

What to call these emerging products is a matter of some debate.  Proponents call them such things as in vitro, lab-based, vat-grown, or clean.

The meat industry wants them called artificial, synthetic, or fake.  It publishes a flier called “Fake Meat Facts.”

The proposed plan calls for the FDA to regulate the collection of animal cells, cell banks, and cell growth—the processes.  USDA will oversee production, as it does for live animals and poultry.

Much must be at stake.  The agencies’ framework is proactive; the products are not expected to be marketed for several years.

The meat industry is relieved that USDA is in charge.

National Cattlemen’s Beef Association President Jennifer Houston said, “The formal agreement announced today solidifies USDA’s lead oversight role in the production and labeling of lab-grown fake meat products.”

“This is what NCBA has been asking for, and it is what consumers deserve,” Houston said.

The market for these products is expected to be huge, but questions remain:

• Lab-based: Is it really environmentally friendly?
• And yes, more research is needed.

We will be hearing a lot more about these products as they head to market.

My monthly (first Sunday) column in the San Francisco Chronicle is now out, this time on the horsemeat scandal.

Q: It makes me sick to think that anyone could eat horsemeat. I don’t see how it could get into so many foods. Tell me how I can be sure I’m not eating it.

A: From this side of the Atlantic, the discovery of horsemeat in European hamburger and frozen dinners is the most riveting of scandals, replete with DNA technology, veterinary drugs, impossible-to-trace supply chains, smuggling, organized crime and outright fraud – not to mention the usual finger-pointing, cover-ups and protestations of shock that accompany food crises.

It is easy to explain how horsemeat got into vast amounts of hamburger and prepared meals. Horses are expensive to house and feed. Something has to be done with them when they are no longer wanted for farming, transport, racing or recreation. Horsemeat is edible, even delicious to some, and costs less than beef.

Complications

In Europe, the supply chains are exceptionally complicated, involving countless companies in more than 21 countries that process, transport or sell horses or horsemeat. The complexity makes it relatively easy to use horses to smuggle people or drugs, to label horsemeat as beef or to slip it into hamburger.

This would just be a matter of economic fraud if people didn’t care whether they ate horsemeat. But some Europeans, and most Americans, care very much. Like you, many people are appalled at the idea of eating any companion animal, let alone one symbolic of the rugged West.

Beyond cultural prohibitions, there are other reasons to avoid eating meat from horses not raised for food. Horses are routinely treated with veterinary drugs, legal and not. The drug traces found in European horsemeat may be too low to cause harm, but hardly seem likely to promote human health.

How long horsemeat has been passed off as European beef is unknown, as is why officials in Ireland decided to do DNA tests on supermarket meals in the first place. Whether done as routine testing or because of a tip, the results were startling. More than one-third of the tested “beef” samples contained horsemeat. Later tests in Great Britain identified “beef” meals made entirely from horsemeat.

This, as the Guardian’s writer Felicity Lawrence wrote in her guide to the scandal, can only be “industrial scale adulteration.”

The ensuing crisis forced many food companies and retailers to recall vast numbers of products, some intended for school meals. Nestlé (no relation) recalled pasta meals, but issued assurances that such products do not leave Europe and that none of its American products contains horsemeat-laden European beef.

What to make of this? In our food studies programs at New York University, we discuss food as a marker of cultural identity. People in other nations eat horsemeat. But like you, about 80 percent of Americans are appalled at the idea of eating horsemeat and oppose slaughtering horses for food or any other reason.

Yet horsemeat used to be eaten by Americans (and still is, by some), and even more so by pets. As Malden C. Nesheim and I wrote in our book about the pet food industry, “Feed Your Pet Right,” horse slaughterhouses created pet food companies to dispose of the meat. Through the 1940s, nearly all domestic horsemeat ended up in pet food.

Under pressure from horse lovers and animal welfare advocates, pet food companies replaced horsemeat with meat from other animals. Although horsemeat is permitted in pet food, and in theory could show up in rendered byproducts and meals, no American company would knowingly use it as an explicit item in an ingredient list. One can only imagine the uproar if it did.

Inspection issues

In 2007, Congress blocked the Department of Agriculture from inspecting slaughterhouses, effectively banning their use. As unintended consequences, the 140,000 or so unwanted horses each year had to be transported to slaughterhouses in Canada or Mexico, and populations of neglected and abandoned horses increased. As a result, Congress permitted horse slaughterhouses to reopen last year, but the USDA has yet to authorize inspectors to work in them.

Could American beef be contaminated with horsemeat? We had a similar scandal in the 1950s. But if U.S. officials are testing hamburger for horsemeat DNA these days, they aren’t saying.

Because horsemeat is not produced here, it won’t be in butcher shops or supermarkets – unless the stores imported it or acquired contaminated products before the recalls, or unless the USDA assigns inspectors and allows horse slaughterhouses to reopen. Right now, without DNA testing, you can’t be sure.

You find this alarming? Short of going vegetarian, you have an option: Buy kosher meat. Jewish dietary laws prohibit horsemeat – horses are not ruminants and do not have cloven hooves – and kosher slaughterhouses are diligent about excluding forbidden animals.

This gives the horsemeat scandal one clear winner: Sales of kosher meat are booming.

The unfolding drama around Europe’s horsemeat scandal is a case study in food politics and the politics of cultural identity.

Cultural identity?  They (other people) eat horsemeat.  We don’t.

Most Americans say they won’t eat horsemeat, are appalled by the very idea, and oppose raising horses for food, selling their meat, and slaughtering horses for any reason.

These attitudes have created dilemmas.  Since Congress effectively banned horse slaughter in 2006, roughly 140,000 horses a year have been transported to Canada and Mexico to be killed.  Whether this is better or worse for the horses is arguable.  Some—perhaps most—of that meat will be exported as food.

As Mal Nesheim and I wrote in our book about the pet food industry, Feed Your Pet Right, most—more than 90%—of domestic horsemeat ended up in pet food (the rest was eaten or shipped to Europe).  In the 1920s, horse slaughterhouses started pet food companies as a means to dispose of the meat.  Horsemeat remained a major ingredient of dog foods throughout the 1940s.

Since then, pet food companies replaced horsemeat with meats from other animals.  Although it continues to be permitted in pet food, I’m not aware of any company that would dare use it.  It would have to be disclosed on package labels.

That brings me to the European horsemeat crisis, one brought about by advances in DNA technology that allow officials to test for species in foods.

I’m indebted to Joe O’Toole, president of Lucullus, a French specialty food company, for keeping me up to date on the unfolding saga of how horsemeat got into European hamburger and so many other foods.  He sent me links to early stories:

The problem first emerged earlier in January when the Food Safety Authority of Ireland handed over results of DNA tests it had carried out on burgers produced in Ireland for sale in the UK. Samples from 10 of 27 products sourced from three processing plants had tested positive for horse DNA. One sample is said to have contained 29 percent horse.

As the article explained, the immediate response was “a relatively faultless exercise in damage control.”  Food processors immediately recalled their products and Tesco, Britain’s largest supermarket chain, placed an ad and followed it up with a video apology.  This is viewed as excellent damage control.  Although Tesco shares dropped by 1 percent for a loss of  $475 million, it could have been worse.  

Leaving aside the cultural prohibitions against eating horsemeat, here’s what I find fascinating:

• DNA technology made this possible.
• The supply chain is so complicated and involves so many countries—Romania, Ireland, Netherlands, Spain, Poland, France, and, no doubt, others—that where the meat comes from is impossible to trace.
• The finger pointing  over who is to blame.
• The enormous number of companies involved.
• The idea that this is a drug issue (horses are treated with drugs).
• The idea that horse transport is used as a cover for smuggling (drugs and people).
• The involvement of organized crime (if selling horsemeat is illegal…).

By far the best place to start on this story is Felicity Lawrence’s Horsemeat Scandal: The Essential Guide, in The Guardian. She did this as a Q and A:

1. Where did the horsemeat scandal begin?

2. Where did the horse and pig found by the Irish in beef products come from?

3. Why did some products contain so much more horse than others?

4. How did the rest of Europe get involved?

5. Is the source of the Irish horsemeat the same as the French one?

6. Why are the supply chains so complex?

7. Why has it happened?

8. How is the meat industry regulated?

9. What about industry claims that it has full traceability?

10. What happened to government control of food safety and standards?

11. Where do the horses come from?

12. What part do UK horse abattoirs play?

13. Why are governments talking about organised crime?

14. Is it a health problem?

I will have more to say about this later, as more details emerge.  Stay tuned!

Addition, February 27: Australia Food Safety News offers this terrific infographic on the scandal.

By this time, you must have heard about the study in Clinical Infectious Diseases sponsored by the Pew Charitable Trusts.  The study found nearly half of supermarket meat and poultry samples to be contaminated with Staphylococcus aureus. Half of the contaminated samples were resistant to multiple antibiotics.

Staph causes awful infections.  When I was a child, my mother had a Staph infection that kept her out of commission for what seemed like months in that pre-antibiotic era.  Antibiotics can keep Staph under control, but not if the Staph are antibiotic-resistant.   Staph resistant to multiple drugs are a clear-and-present danger.  No wonder this study got so much attention.

The study provides strong support for the idea that we ought to be reducing use of antibiotics as growth promoters in farm animals, an idea strongly supported by the CDC.

Even though 80% of U.S. antibiotic use is for farm animals, the meat industry strong opposes any proposal to change its practices.

The National Cattleman’s Beef Association responds by attacking the science:

Calling into question the safety of U.S. beef without conclusive scientific evidence is careless and misleads consumers. Pew Charitable Trusts, an agenda-driven organization on this issue, funded this study, which concludes that its extremely small sample size was ‘insufficient to accurately estimate prevalence rates’ and that ‘public health relevance of this finding is unclear.’ The study’s authors clearly call into question the validity of their own study. The bottom-line is U.S. beef is safe and is part of a healthy, well-balanced diet.

The American Meat Institute reassures the public that meat is safe.  After all, you are going to cook your meat, aren’t you?  In any case, the responsibility rests with you.

While the study claims that the many of the bacteria found were antibiotic resistant, it does note that they are not heat resistant.  These bacteria are destroyed through normal cooking procedures, which may account for the small percentage of foodborne illnesses linked to these bacteria.

As with any raw agricultural product, it is important to follow federal safe handling recommendations included on every meat and poultry package that urge consumers to wash hands and surfaces when handling raw meat and poultry and to separate raw from cooked foods to ensure that food is safe when served.

These sound like the arguments that the meat industry has made for years for Salmonella and E. coli O157:H7.

I see this study as another reason why we need better food safety regulation, and the sooner the better.

Postscript: Bill Marler reports that he had 100 samples of chicken tested from Seattle markets:

IEH Labs found S. aurea [sic], or staph, in 42 percent of the samples overall and Campylobacter in 65 percent. The supermarket chicken was contaminated with other pathogens as well: 19 percent of the samples tested positive for Salmonella, one tested positive for Listeria, and 10 percent showed the presence of the methicillin-resistant S. aureus (MRSA). In an unusual finding, one of the chicken samples tested positive for E. coli 0126, Shiga-toxin producing E. coli (STEC) bacteria more likely to be a contaminant of beef than poultry. Organic Chicken proved to be slightly less contaminated than nonorganic with 7 of the 13 (54%) testing positive for harmful bacteria.

As I said….

The FDA issued its most recent report on antibiotics late last year: 2022 Summary Report On Antimicrobials Sold or Distributed for Use in Food-Producing Animals, along with Antimicrobial Sales and Distribution Data 2013-2022.

It did this in response to public concerns about antibiotic use in food animals: if antibiotics are used at subtherapeutic doses, they might induce microbial resistance to drugs used to treat diseases in humans.

This is not a theoretical concern.  It’s a real problem.

It’s also a problem because the vast majority of antibiotics were used as growth promoters or to prevent infections in animals crowded together—not to treat disease.

In 2014 or so, the FDA ruled that medically important antibiotics could no longer be used as growth promoters in farm animals.  That rule went into effect in 2017.

The FDA’s good news: the amounts of antibiotics used in farm animals has declined since then.

Are medically important antibiotics still used for non-therapeutic purposes?

The report says that since 2017, zero antibiotics are administered for growth promotion.

If you wonder whether this is really true (as I do), consider that $11.2 million kilograms of antibiotics were used in food animals in 2022.  This is a decrease from the 15.6 million kg used in 2015, but still a lot.

Of these drugs, 63% are administered in feed, and 31% in water.

All antibiotics still used as growth promoters are supposed to be drugs not used in human medicine.

I’m not the only skeptic on this one.  See:

I.  The Bureau of Investigative Journalism’s Antibiotics in agriculture: The blurred line between growth promotion and disease prevention.

In an investigation published today, the Bureau revealed how US farm animals are still being dosed with antibiotics vital to human health, despite efforts to curtail such usage and combat the spread of deadly superbugs. We also found that a regulatory loophole means that using antibiotics to make animals fatter – a process known as growth promotion – is technically still possible, despite this practice being banned in January 2017.

II.  Nature: Antibiotic use in farming set to soar despite drug-resistance fears. Analysis finds antimicrobial drug use in agriculture is much higher than reported.

III.  Vox: Big Meat just can’t quit antibiotics: Meat production is making lifesaving drugs less effective. Where’s the FDA?

According to an analysis published in September by the Natural Resources Defense Council and One Health Trust, medically important antibiotics are increasingly going to livestock instead of humans. In 2017, the meat industry purchased 62 percent of the US supply. By 2020, it rose to 69 percent.

Does the FDA check?  It has guidance for industry on The Judicious Use of Medically Important Antimicrobial Drugs in Food-Producing Animals, but this guidance is non-binding.

Obviously, the FDA needs to do more.  Its officials told Vox:

Mexico has issued new dietary guidelines.

https://www.gob.mx/cms/uploads/attachment/file/826673/Gui_as_Alimentarias_2023_para_la_poblacio_n_mexicana.pdf

1. Breastfeed babies for the first 6 months and then continue until age 2 along with other nutritious foods.
2.  Eat more vegetables and fruits.
3. Eat beans.
4. Choose whole grains.
5. Eat less beef and processed meats.
6. Avoid ultra-processed foods.
7. Drink water.
8. Avoid alcohol.
9. Be physically active.
10. Enjoy meals with family and friends.

I’m looking forward to reading a case study on how the public health institute got these through the political process.

If people follow these guidelines, these industries will be in trouble:

• Infant formula
• Beef
• Processed meats
• Ultra-processed foods
• Sugar-sweetened beverages
• Alcohol

People will be healthier!  These industries will also be in trouble.

• Pharmaceutical drugs
• Private medicine
• Insurance companies? (you might think they would benefit, but they make so much money on illness—this one is complicated)

I hope the new U.S. Dietary Guidelines will find these inspiring.

The FDA says use of medically important antimicrobial drugs in food animals decreased by 3% between 2019 and 2020  (For details, see the full report).

Is this good news or not.  Use is down from 2015-2016, but up from 2017.  As Wired puts it, “Antibiotic Use in US Farm Animals Was Falling. Now It’s Not.”

According to the Natural Resource Defense Council, use of antibiotics as growth promoters in food animals is still a big problem, with lots more going for use in animals than in humans.

Or, to be a bit more precise:

The Pew Foundation thinks much more needs to be done to limit use of antibiotics in food animals.

FDA: get on this please.

Harold McGee.  Nose Dive: A Field Guide to the World’s Smells.  Penguin Press, 2020.

Harold McGee, author of the astonishing On Food and Cooking, sent me a copy of his equally astonishing new book, this one an encyclopedia of the smells of everything—the “osmocosm.”

I am happy to have it.  He’s produced a life-changing book.  I will never think of smells in the same way again.

For starters, the book is brilliantly designed with elegant charts, key terms in bold, and chemical structures (yes!) right next to the terms in miniature on a light grey background, set off from the text but right there where they are needed.  Here’s an example from the pages that Amazon.com makes available.  This excerpt comes from a section on the smells of chemical compounds found in interstellar space (p. 19—and see my comment on the page number at the end of this post).

Interstellar space?  Well, yes.  Also animals, pets, and human armpits, along with flowers, spices, weeds, fungi, stones (they have bacteria and fungi on them), asphalt, perfumes, and everything else that smells or stinks—as well as foods, of course.

McGee must have had fun writing this.

It’s exactly becasue CAFOs [Concentrated Animal Feeding Operations] are offensive and harmful that the volatiles of animal excrement have been so well studied.  Crazily but appropriately, chemists borrow the terminology of top, middle, and base notes from the perfume worls (see page 477) to describe the smells of CAFOs.  The top notes, very volatile and quickly dispersed, are ammonia and hydrogen sulfide.  The more persistent middle notes include amines, thiols and sulfides, aldehydes and alcohols and ketones.  The constantly present base notes are the short-chain straight and branched acids, cfresol and other pehnolics, and skatole.  In a 2006 study of swine and beef cattle operations, barnyard cresol was identified as the primary offensive odor, and could be detected as far as ten miles (sixteen kilometers) downwind.  It’s probably the first long-distance hint I get of that I-5 Eau de Coalinga (p. 71).

But let me be clear: this is an encyclopedia, demanding close attention to the chemistry.  Sentences like this one come frequently: “The branched four-carbon chain (3-sulfanyl-2-methyl butanol) has its branch just one carbon atom over from the otherwise identical molecule in cat pee” (p.121).

But this blog is about food.  McGee’s discussion of food smells are riveting.  For example:

• The standard basil varieties in the West today mainly produce varying proportions of a coupld of terpenoids, flowery linalook and fresh eucalyptol, and the clove- and anise-smelling benzenoids eugenol and estragole.  But when it comes to a dish in which basil stars—peto alla genovese, the Ligurian pasta sauce of pounded basil, garlic, nuts, and cheese—Italians are more particular (p. 255).
• In 2014, I made a pilgrimage to a celebrated durian stall in the outskirts of Singapore and found that most of the half-dozen varieties I tried tasted of strawberries and a mix of fried onions and garlic.  I enjoyed them enough to smuggl one into my hotel room…After just an hour or two its royal presence filled the room and became unbearable.  I had no choice but regicide, and disposed of the body like coCanned sntraband drugs, flushing it in pieces down the toilet (p. 333).
• The dominant note [in beef stews], described as “gravy-like,” came not from the meats, but from the onions and leeks!  The volatile responsible turned out to be a five-carbon, one-sulfur chain with a methyl decoration, a mercaptomethyl pentanol, MMP for short.  It is formed by a sequene of reactions, the first causaed by heat-sensitive onion enzymes, then ordinary chemical reactions that are accelerated by heat.  So its production is encouraged by chopping or pureeing these alliums (but not garlic) well before cooking them to let the enzymes do their work, the cooking slowly for several hours  (p. 513).
• Canned sweet corn is dominated by seaside-vegetal dimethyl sulfide, acetyl pyrroline, and a corny thiazole (p. 519).
• Swiss Appenzeller is notably strong in sweaty-foot branched acids (p. 567).

It should be clear from these excerpts that this is a reference work—a field guide—just as advertised.  If you read it, you will learn more than you ever dreamed possible about the volatile molecules that we can and do smell.

Nose Dive will go right next to On Food and Cooking on my reference shelf.

But uh oh.  How I wish it had a better index. 

For a book like this, the index needs to be meticulously complete—list every bold face term every time it appears—so readers can find what we are looking for.  This one is surprisingly unhelpful.

I found this out because I forgot to write down the page number for the fatty acid excerpt shown above.  I searched the index for most of the key words that appear in the clip: fatty acids, short and branched; butyric; methylbutyric; hexanoic; cheesy; intersteller space. No luck.  I had to check through all of the fatty acid listings and finally found it under “fatty acids, and molecules in asteroids, 19.”   Oh.  Asteroids.  Silly me.

I also forgot to note the page for the CAFO quote.  CAFO is not indexed at all, even though it appears in bold on the previous page, and neither does its definition, Concentrated Animal Feeding Operation.

McGee refers frequently to “Hero Carbon,” the atom basic to odiferous molecules.  I couldn’t remember where he first used “Hero” and tried to look it up.  Not a chance.

This book deserves better, alas.

Penguin Press:  this needs a fix, big time.