Food Politics

by Marion Nestle
Feb 9 2016

Studies funded by a garlic supplement maker find specific health benefits for garlic. The score: 119/11.

I’m having trouble keeping up with industry-sponsored nutrition research so will use this week’s posts to catch up.  I’ll start with this one.

Nutrition journals often publish supplements on specific themes that are paid for by outside parties, food industry groups among them.  The February 2016 issue of the Journal of Nutrition contains a supplement with the papers from the 2014 International Garlic Symposium: “Role of Garlic in Cardiovascular Disease Prevention, Metabolic Syndrome, and Immunology.”

To distinguish supplement papers from peer-reviewed journal articles, citations give page numbers with the letter S.  The Journal of Nutrition’s exceptionally clear policy on supplement publications explains that organizers are expected to pay page charges of $75 per article and $300 per published page plus additional editorial costs as needed.  It views supplements as paid advertisements and requires full disclosure of funding sources.

Here’s the disclosure for the garlic supplement.

The symposium was sponsored by the University of California, Los Angeles School of Medicine and the University of Florida and co-sponsored by the American Botanical Council; the American Herbal Products Association; the ASN [American Society for Nutrition]; the Japanese Society for Food Factors; the Japan Society for Bioscience, Biotechnology, and Agrochemistry; the Japan Society of Nutrition and Food Science; and the Natural Products Association. The symposium was supported by Agencias Motta S.A.; Bionam; Eco-Nutraceuticos; Healthy U 2000 Ltd.; Magna; Mannavita Bvba; MaxiPharma; Medica Nord A.S.; Nature’s Farm Pte. Ltd.; Nature Valley W.L.L.; Organic Health Ltd.; Oy Valioravinto Ab; Purity Life Health Products L.P.; PT Nutriprima Jayasakti; Vitaco Health Ltd.; Vitae Natural Nutrition; Sanofi Consumer Health Care; Wakunaga Pharmaceutical Co., Ltd.; and Wakunaga of America Co., Ltd. The Chair of the conference and Scientific Program Coordinator for the supplement publication was Matthew J Budoff, Harbor-UCLA Medical Center, Torrance, CA. Scientific Program Coordinator disclosures: MJ Budoff has been awarded research grants from Wakunaga of America Co., Ltd., and received an honorarium for serving as Chair of the conference. Vice-Chair and Supplement Coordinator for the supplement publication was Susan S Percival, University of Florida, Gainesville, FL. Supplement Coordinator disclosures: SS Percival has been awarded research grants from Wakunaga of America Co., Ltd., and received an honorarium for serving as Vice-Chair of the conference. Publication costs for this supplement were defrayed in part by the payment of page charges. This publication must therefore be hereby marked “advertisement” in accordance with 18 USC section 1734 solely to indicate this fact. The opinions expressed in this publication are those of the authors and are not attributable to the sponsors or the publisher, Editor, or Editorial Board of The Journal of Nutrition [my emphasis].

Comment on scoring: Because they were presented at a symposium sponsored by food and supplement companies, all papers raise questions about industry sponsorship.  That is why the Journal requires every paper in the supplement to repeat this funding disclosure in its entirety.

But for this particular symposium, some of the papers report additional funding by Wakunaga of America, a company that, no surprise, manufactures garlic supplements.

All of the papers produced results useful to the sponsor.  Some of them, however, were independently funded and the authors report no links to the sponsor other than having given a talk at the meeting.  They did not disclose who paid for travel and hotels and without any way to check, I must assume that they paid their own expenses to the meeting in San Diego.  For the purposes of scoring, I’m not counting them as industry-funded, even though their presence at the symposium made it seem more scientifically credible.

Garlic Lowers Blood Pressure in Hypertensive Individuals, Regulates Serum Cholesterol, and Stimulates Immunity: An Updated Meta-analysis and Review.  Karin Ried.  J Nutr. 2016; 146:389S-396S doi:10.3945/jn.114.202192.

  • Conclusions: Our review suggests that garlic supplements have the potential to lower blood pressure in hypertensive individuals, to regulate slightly elevated cholesterol concentrations, and to stimulate the immune system. Garlic supplements are highly tolerated and may be considered as a complementary treatment option for hypertension, slightly elevated cholesterol, and stimulation of immunity.
  • Author disclosures: K Ried, no conflicts of interest. K Ried received travel sponsorship from Wakunaga of America Co. Ltd. to attend the 2014 International Garlic Symposium.
  • Score: industry-positive

Chemical Assignment of Structural Isomers of Sulfur-Containing Metabolites in Garlic by Liquid Chromatography−Fourier Transform Ion Cyclotron Resonance−Mass Spectrometry.  Ryo Nakabayashi, Yuji Sawada, Morihiro Aoyagi, Yutaka Yamada, Masami Yokota Hirai, Tetsuya Sakurai, Takahiro Kamoi, Daryl D Rowan, and Kazuki Saito.  J. Nutr. 2016; 146:397S-402S doi:10.3945/jn.114.202317.

  • Conclusion: The ability to discriminate between such geometric isomers will be extremely useful for the chemical assignment of unknown metabolites in MS-based metabolomics.
  • Supported, in part, by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan; Japan Advanced Plant Science Network; Japan Science Technology Agency (JST), Strategic International Collaborative Research Program (SICORP); and JST, Strategic International Research Cooperative Program (SICP).
  • Score: industry-neutral

Garlic-Derived Organic Polysulfides and Myocardial Protection.  Jessica M Bradley, Chelsea L Organ, and David J Lefer.  J. Nutr. 2016; 146:403S-409S doi:10.3945/jn.114.208066.

  • Conclusion: The beneficial health effects of garlic on cardiovascular health are dependent on multiple mechanisms. Furthermore, the mechanisms of action may be mediated by the active components in garlic.
  • Supported by grants from the National Heart, Lung, and Blood Institute (1R01 HL092141, 1R01 HL093579, 1U24 HL 094373, and 1P20 HL113452; to DJL) and by the Louisiana State University Health Foundation in New Orleans.
  • Score: Industry-neutral

Aged Garlic Extract Inhibits Human Platelet Aggregation by Altering Intracellular Signaling and Platelet Shape Change.  Khalid Rahman, Gordon M Lowe, and Sarah Smith.  J. Nutr. 2016; 146:410S-415S doi:10.3945/jn.114.202408

  • Conclusion: These results indicate that AGE [Aged Garlic Extract] inhibits platelet aggregation by increasing cyclic nucleotides and inhibiting fibrinogen binding and platelet shape change.
  • Funding: Supported by a grant from Wakunaga of America Co. Ltd.  K Rahman and GM Lowe were in receipt of a grant from Wakunaga of America Co., Ltd. S Smith, no conflicts of interest.
  • Score: industry-positive

Garlic and Heart Disease.  Ravi Varshney and Matthew J Budoff.  J. Nutr. 2016; 146:416S-421S doi:10.3945/jn.114.202333

  • Conclusion: We conclude that garlic supplementation has the potential for cardiovascular protection based on risk factor reduction (hypertension and total cholesterol) and surrogate markers (CRP, PWV, and CAC) of atherosclerosis.
  • Disclosures: The authors report no funding received for this study.  R Varshney, no conflicts of interest. MJ Budoff receives funding from Wakunaga of America Co., Ltd.
  • Score: industry-positive

The Role of Adiponectin in Cardiometabolic Diseases: Effects of Nutritional Interventions.  Patricio Lopez-Jaramillo.  J. Nutr. 2016; 146:422S-426S doi:10.3945/jn.114.202432

  • Conclusions: Recently, it was reported that the administration of aged garlic extract and a single food intervention with pistachios can increase adiponectin concentrations in individuals with metabolic syndrome. Moreover, the Mediterranean diet is associated with higher adiponectin concentrations. Additional studies are needed to evaluate the potential benefits of increasing adiponectin by nutritional interventions in the treatment and prevention of cardiometabolic diseases.
  • Funding: The author reports no funding received for this study.
  • Score:  Industry-neutral

Aged Garlic Extract Reduces Low Attenuation Plaque in Coronary Arteries of Patients with Metabolic Syndrome in a Prospective Randomized Double-Blind Study.  Suguru Matsumoto, Rine Nakanishi, Dong Li, Anas Alani, Panteha Rezaeian, Sach Prabhu, Jeby Abraham, Michael A Fahmy, Christopher Dailing, Ferdinand Flores, Sajad Hamal, Alexander Broersen, Pieter H Kitslaar, and Matthew J Budoff.  J. Nutr. 2016; 146:427S-432S doi:10.3945/jn.114.202424

  • Conclusions: This study indicates that the %LAP [Low Attenuation Plaque] change was significantly greater in the AGE group than in the placebo group. Further studies are needed to evaluate whether AGE has the ability to stabilize vulnerable plaque and decrease adverse cardiovascular events.
  • Disclosures: While the study was funded by Wakunaga of America Co., Ltd., the authors are solely responsible for the design, all study analyses, the drafting and editing of the paper and its final contents…S Matsumoto, R Nakanishi, D Li, A Alani, P Rezaeian, S Prabhu, J Abraham, MA Fahmy, C Dailing, F Flores, S Hamal, and A Broersen, no conflicts of interest. PH Kitslaar is employed by Medis Medical Imaging Systems and has a research appointment at the Leiden University Medical Center. MJ Budoff receives funding from Wakunaga of America Co., Ltd.
  • Score: industry-positive

Aged Garlic Extract Modifies Human Immunity.  Susan S Percival.  J.  Nutr. 2016; 146:433S-436S doi:10.3945/jn.115.210427

  • Conclusions: These results suggest that AGE supplementation may enhance immune cell function and may be partly responsible for the reduced severity of colds and flu reported. The results also suggest that the immune system functions well with AGE supplementation, perhaps with less accompanying inflammation.
  • Funding: Support for this research was provided by Wakunaga of America Co., Ltd.  Author disclosures: SS Percival received travel expenses to the conference where this work was presented.
  • Score: industry-positive

Bioavailability of Alfrutamide and Caffedymine and Their P-Selectin Suppression and Platelet-Leukocyte Aggregation Mechanisms in Mice.  Jae B Park.  J. Nutr. 2016; 146:437S-443S doi:10.3945/jn.114.202473

  • Conclusions: These data show the adequate bioavailability of alfrutamide and caffedymine and their different mechanisms of suppressing PSE and PLA: alfrutamide exerts its effects only via COX inhibition, whereas caffedymine works through both COX inhibition and cAMP amplification.
  • Funding: Supported by the USDA (project 8040-51000-057-00).
  • Score: Industry-neutral

Garlic Influences Gene Expression In Vivo and In Vitro.  Craig S Charron, Harry D Dawson, and Janet A Novotny.  J. Nutr. 2016; 146:444S-449S doi:10.3945/jn.114.202481

  • Conclusion: Measuring mRNA gene expression in whole blood may provide a unique window to understanding how garlic intake affects human health.
  • Support: CSC, HDD, and JAN were supported by the USDA.
  • Score: Industry-neutral.

Development of an Analytic Method for Sulfur Compounds in Aged Garlic Extract with the Use of a Postcolumn High Performance Liquid Chromatography Method with Sulfur-Specific Detection.  Toshiaki Matsutomo and Yukihiro Kodera.  J. Nutr. 2016; 146:450S-455S doi:10.3945/jn.114.208520

  • Conclusion: We developed a rapid postcolumn HPLC method for both qualitative and quantitative analyses of sulfur compounds, and this method helped elucidate a potential mechanism of cis-S1PC and SAMC action in AGE.
  • Acknowledgment: The authors thank Takami Oka of Wakunaga Pharmaceutical Co., Ltd. for his kind guidance for this study and critical review of the manuscript.
  • Score: Industry-positive

Pharmacokinetics of S-Allyl-L-cysteine in Rats Is Characterized by High Oral Absorption and Extensive Renal Reabsorption.  Hirotaka Amano, Daichi Kazamori, and Kenji Itoh.  J. Nutr. 2016; 146:456S-459S doi:10.3945/jn.114.201749

  • Conclusion: The pharmacokinetics of SAC in rats were characterized by high oral absorption, limited metabolism, and extensive renal reabsorption, all of which potentially contribute to its high and relatively long-lasting plasma concentrations.
  • Acknowledgment: We thank Takami Oka of Wakunaga Pharmaceutical Co. for his valuable advice, critical reading of the manuscript, and helpful suggestions.
  • Score: Industry-positive

Aged Garlic Extract Suppresses the Development of Atherosclerosis in Apolipoprotein E–Knockout Mice.  Naoaki Morihara, Atsuko Hino, Takako Yamaguchi, and Jun-ichiro Suzuki. J. Nutr. 2016; 146:460S-463S doi:10.3945/jn.114.206953

  • Conclusion: These data suggest that the antiatherosclerotic activity of AGE is at least partly due to the suppression of inflammation and lipid deposition in the vessels during the early stage of atherosclerotic development in ApoE-KO mice.
  • Acknowledgment: We thank Takami Oka of Wakunaga Pharmaceutical Co., Ltd., for his helpful advice, encouragement, and critical reading of this manuscript; Yukihiro Kodera of Wakunaga Pharmaceutical Co., Ltd., for the preparation of AGE; and Tadamitsu Tsuneyoshi of Wakunaga Pharmaceutical Co., Ltd., for his technical advice.
  • Score: Industry-positive

This makes 8 industry-positives from this journal supplement.

But let me add one more on this topic, sent by a reader:

The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: the AGE at Heart trial.  Karin Ried Nikolaj Travica, Avni Sali.  Integrated Blood Pressure Control, 27 January 2016.

  • Conclusion: Our trial suggests that aged garlic extract is effective in reducing peripheral and central blood pressure in a large proportion of patients with uncontrolled hypertension, and has the potential to improve arterial stiffness, inflammation, and other cardiovascular markers in patients with elevated levels. Aged garlic extract was highly tolerable with a high safety profile as a stand-alone or adjunctive antihypertensive treatment.
  • Funding: This trial was supported by a grant from Wakunaga of America Co Ltd, who sup­plied trial capsules and provided funding for costs of tests and research assistance. Wakunaga of America was not involved in study design, data collection, analysis, or prepa­ration of the manuscript…The authors report no conflicts of interest in this work.
  • Score: industry-positive, of course.

This brings the score since last March to 119 industry-positives/11 industry-negatives.

Feb 8 2016

McDonald’s Australia style: Why can’t they do this in the USA?

The McDonald’s closest to the part of the University of Sydney where I am working temporarily, looks like no McDonald’s I’ve ever seen.

Under The Corner, it says McCafe.  This place is a Maccas, as they call them here.

IMG_20160201_1634024

The Corner offers an acceptable salad bar.

And slogans:

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An improvement?  Yes, but why not in the U.S.?

Feb 6 2016

Weekend Reading: Forked! (It’s just out)

Saru Jayaraman.  Forked: A New Standard for American Dining.  Oxford University Press, 2016.

I did a blurb for this one, for good reason.  Saru Jayaraman is doing important work on behalf of low-wage restaurant workers, most of them immigrants and women.  This book is her manifesto.

That restaurant workers can be paid as little as $2.13 an hour, and require taxpayer-supported food assistance to survive, is a national scandal.  Forked tells the stories of enlightened restaurant owners who treat and pay workers decently, with immediate returns in employee loyalty, better customer service—and profits.  This book should inspire all restaurant owners to take the “high road,” and all of us restaurant customers to demand that they do.

Read it and join the campaign for decent pay for restaurant workers, farm workers, and everyone else who is excluded from minimum-wage requirements.

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Feb 5 2016

Chipotle’s food safety woes

Conspiracy theorists cannot believe that Chipotle’s ongoing food safety problems—and its consequent legal woes—can be due to anything other than deliberate sabotage.  Much as I love conspiracy theories—and my favorite is to blame the Center for Consumer Freedom—I suspect the problems are related more to supply-chain issues and the need to establish a stronger internal culture of food safety.  This means getting every employee to follow food safety rules to the letter—but also in spirit.

The company has done the right thing by recruiting help from a top food-safety consulting firm.

In the meantime, here’s what’s happening to its stock prices.Capture

Additions:

Feb 4 2016

Five more industry-sponsored marketing studies. The score 110:11.

Here are some recent additions to my ever-growing collection of industry-funded food and nutrition studies or commentaries with results favorable to the sponsor’s interests.  These bring the total since last March to 110 with favorable results versus 11 with those that must have disappointed the sponsor.

Reduced dietary intake of simple sugars alters perceived sweet taste intensity but not perceived pleasantness. Paul M Wise, Laura Nattress, Linda J Flammer, and Gary K Beauchamp. Am J Clin Nutr 2016; 103:50-60.  doi:10.3945/ajcn.115.112300

  • Conclusions: This experiment provides empirical evidence that changes in consumption of simple sugars influence perceived sweet taste intensity. More work is needed to determine whether sugar intake ultimately shifts preferences for sweet foods and beverages.
  • Supported by PepsiCo Inc. and Monell Chemical Senses Center institutional funds.
  • Comment: This study shows that if you eat less sugar, even low-sugar foods taste sweet.  Soft drink companies are under pressure to reduce sugar.  If these results are correct, soda companies ought to be able to get away with reducing their sugar content—at least if customers get used to consuming less sugar and accept drinks that are not so intensely sweet. 

Consuming yellow pea fiber reduces voluntary energy intake and body fat in overweight/obese adults in a 12-week randomized controlled trial.  Jennifer E. Lambertemail, Jill A. Parnellemail, Jasmine M. Tunnicliffe, Jay Han, Troy Sturzenegger, Raylene A. Reimer. Clinical Nutrition, Article in press published online January 11, 2016.  DOI: http://dx.doi.org/10.1016/j.clnu.2015.12.016

  • Conclusions:  In the absence of other lifestyle changes, incorporating 15 g/day yellow pea fiber may yield small but significant metabolic benefits and aid in obesity management.
  • Funding: The study was funded by Alberta Innovates Bio Solutions, Alberta Innovates Health Solutions and Alberta Pulse Growers Commission.

Effect of flavored milk vs plain milk on total milk intake and nutrient provision in children.  Flavia Fayet-Moore. Nutrition Reviews Jan;74(1):1-17. doi: Here’10.1093/nutrit/nuv031. Epub 2015 Nov 3.

  • Conclusions: There is no association between flavored milk intake and weight status among normal-weight children, and some contradictory effects of flavored milk intake have been observed in subgroups of overweight children. Flavored milk is a palatable beverage choice that helps children to meet calcium targets.
  • Financial disclosures. The author received a research grant from Nestlé Australia Ltd to conduct.

Does milk consumption contribute to cardiometabolic health and overall diet quality?  Lamarche B, Givens I, Soedamah-Muthu S, Krauss RM, Jakobsen MU, Bischoff-Ferrari HA, Pan A, Després J-P, Canadian Journal of Cardiology (2016), doi: 10.1016/j.cjca.2015.12.033.

  • Conclusion: The evidence to date suggests a neutral effect of milk intake per se on several health-related outcomes. The possibility that milk intake is simply a marker of higher nutritional quality diets cannot be ruled out and needs to be further examined in future studies.
  • Authors’ disclosures (in supplementary online material): BL is Chair of Nutrition at Laval University, which Board of Directors include a representative from Provigo-Loblaws. BL has received funding from Agri-food and Agriculture Canada, the Dairy Farmers of Canada (DFC), Dairy Australia and Dairy Research Institute to study dairy and health. He serves as the Chair of the independent, peer-review Expert Scientific Advisory Council of DFC. BL has also received honoraria from DFC as invited speaker in various conferences. MUJ has received honoraria from the Global Dairy Platform to review the observational epidemiological evidence of associations between intake of trans fatty acids and risk of CHD and from the European Milk Forum as an invited speaker at symposia. IG is Chair of Food Chain Nutrition at the University of Reading. He has received funding from the UK Dairy Council, AHDB Dairy, the Barham Benevolent Trust and the UK Medical Research Council for studies on dairy and health. He has also received honoraria from the Dairy Council as an invited speaker at various conferences. He serves on various committees including being the Deputy Chair of the UK Food Standards Agency committee concerned with food chain related aspects of food safety. SSSM previously received unrestricted research grants from Global Dairy Platform, Dairy Research Institute and Dairy Australia for projects related to dairy effects on lipoproteins and mortality. RMK has received grant support from Dairy Management, Inc. Other authors have no disclosures related to the content of this paper.

Including “Added Sugars” on the Nutrition Facts Panel: How Consumers Perceive the Proposed Change.  Idamarie Laquatra, Kris Sollid, Marianne Smith Edge, Jason Pelzel, John Turner.  Published Online: June 09, 2015. DOI: http://dx.doi.org/10.1016/j.jand.2015.04.017|

  • Conclusion: In this analysis, rather than improving consumer understanding about the amount of total sugars in a product, NFPs with “Added Sugars” declarations were misleading and the resulting misperception influenced purchase intent.
  • Statement of potential conflict of interest: No potential conflict of interest was reported by the authors.
  • Funding support: This research was commissioned and funded by the International Food Information Council Foundation and conducted by Turner Research Network of Atlanta, GA. More details about the International Food Information Council Foundation can be found at http://www.foodinsight.org/pages/faqs.
  • Comment: IFIC is funded by food and beverage companies (see SourceWatch).  The FDA is currently considering putting a line for Added Sugars on food labels.  Food companies, understandably, oppose this idea.
Feb 3 2016

Where are we on GMO politics: an update

State GMO labeling bills: While Congress dithers, states are getting busy.  The Sunlight Foundation’s SCOUT database on state GMO legislative initiatives is searchable.  Examples:

Detente between producers of GMO and labeling advocates: USDA Secretary Tom Vilsack held a meeting to attempt to forge some kind of accord between producers of GMO foods and advocates for GMO labels.  By all reports, it didn’t work.  Earlier, Vilsack tried to negotiate detente between GMO producers and producers of organic foods.  That didn’t work either.

GMO Salmon: The FDA says it will not allow imports of GMO salmon.  Since GMO salmon are produced in Canada and Panama, this action in effect bans GMO salmon from the US food supply.  The FDA is working on labeling guidelines and probably wants them out before allowing imports.

Monsanto’s conversation:  Monsanto’s interactive website invites you to be part of the conversation.  Aything you like.  Someone from Monsanto will respond.  This site is clearly keeping Monsanto’s PR staff on its toes. Here is just one example:

Feb 2 2016

Food-Navigator’s Special Edition: Food for kids!

I greatly enjoy Food-Navigator’s collections of articles on specific topics.  Here’s one on marketing foods to kids.

While there is some evidence that the tide may now be turning on childhood obesity, 8.4% of US 2-5 year-olds; 17.7% of 6-11 year-olds and 20.5% of 12-19-year-olds are still obese, and many are lacking in essential nutrients from potassium, dietary fiber and calcium, to vitamin D. So how can the food industry respond to these concerns and develop more nutritious, but appealing snacks, meals and beverages for kids?

Addition, February 3: A reader reminds me that Food-Navigator published a guide to creating successful children’s brands a couple of months ago.

Feb 1 2016

A food politics souvenir of Auckland

On my way to Australia, I stopped in Auckland.

The Auckland train station is clean and beautiful—and a perfect site for advertising Coca-Cola.IMG_20160118_1439519

A short ferry ride lands you in vineyards.

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Food thoughts to ponder early on a Monday morning in Sydney (Sunday afternoon in New York).

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