The study: Assessing the in vivo data on low/no-calorie sweeteners and the gut microbiota. Alexandra R. Lobacha, Ashley Roberts, Ian R. Rowland. Food and Chemical Toxicology 124 (2019) 385–399.
Its conclusion: “The sum of the data provides clear evidence that changes in the diet unrelated to LNCS [low- and no-calorie sweeteners] consumption are likely the major determinants of change in gut microbiota numbers and phyla, confirming the viewpoint supported by all the major international food safety and health regulatory authorities that LNCS are safe at currently approved levels.”
Funding disclosures: Intertek Scientific & Regulatory Consultancy (A.R.L. and A.R.) received financial support from the Calorie Control Council to assist in the preparation of the manuscript. The Calorie Control Council did not contribute to the origination, planning, implementation, or interpretation of this work. The Calorie Control Council did review the content of the complete manuscript; however, A.R. maintained responsibility for the final content.
Comment: Artificial sweeteners are widely suspected on the basis of questionable evidence to be harmful in one way or another. The industry that makes these sweeteners wants to prove them safe and effective. This was a literature review commissioned by the Calorie Control Council, a trade association for the makers and users of artificial sweeteners, from Intertek Scientific & Regulatory Consultancy, a group that does this kind of work. I would be more confident in conclusions like these if they had been arrived at independently.