Currently browsing posts about: Sponsored-research

I haven’t posted anything about pistachio industry conflicts of interest since 2019 so it’s time for another one.

Here’s a press release sent to me by a reader, Matthew Kadey:

NEW STUDY REVEALS PISTACHIOS ARE AN ANTIOXIDANT POWERHOUSE…Antioxidant-rich foods are regularly encouraged as part of a healthy lifestyle, and research suggests that a diet high in antioxidants may even help to reduce the risk of death.¹ While certain fruits and vegetables are often thought of as high-antioxidant foods, a new study conducted by Cornell University and published in the journal, Nutrients, produced surprising results². Pistachios have a very high antioxidant capacity, among the highest when compared to values reported in research of many foods commonly known for their antioxidant capacity, such as blueberries, pomegranates, cherries, and beets.^3,4,5  (I’ve posted the references at the end).

My first question, as always when I see a press release like this: Who paid for it?

The study: uan, Wang, Bisheng Zheng, Tong Li, and Rui Hai Liu. 2022. Quantification of Phytochemicals, Cellular Antioxidant Activities and Antiproliferative Activities of Raw and Roasted American Pistachios (Pistacia vera L). Nutrients 14, no. 15: 3002. https://doi.org/10.3390/nu14153002

Conclusion:  It is shown that the roasting of pistachios could produce a series of beneficial phytochemical changes, leading to enhanced biological activity. Pistachios are a nutrient-dense food containing a unique profile of good-quality protein, fats, minerals, vitamins, and antioxidants, such as carotenoids and polyphenols, with cellular antioxidant activity. Dietary Guidelines for Americans 2020–2025 suggested including nuts as a health dietary pattern. Further research on antiproliferative activity and mechanisms of action of free-form extracts of roasted pistachios, and more biological activities related cellular antioxidant activity and oxidative stress, are worthy of further investigation.

Funding: This study was partially supported by Innovative Leading Talents Project of Guangzhou Development Zone and 111 Project: B17018, Cornell China Center, and American Pistachio Growers: 2021-09.

Conflicts of Interest: The authors declare no conflict of interest.

Comment: Roasted pistachios are healthy?  No surprise here.  Further research needed?  Also no surprise.  This is another example of an industry-funded study with unimpressive results but plenty of interpretation bias, along with the usual contention that industry funding does not induce conflicts of interest.  Alas, it does.

References to the press release paragraph

¹ Jayedi A, Rashidy-Pour A, Parohan M, Zargar MS, Shab-Bidar S. Dietary Antioxidants, Circulating Antioxidant Concentrations, Total Antioxidant Capacity, and Risk of All-Cause Mortality: A Systematic Review and Dose-Response Meta-Analysis of Prospective Observational Studies. Adv Nutr. 2018 Nov 1;9(6):701-716. doi: 10.1093/advances/nmy040. PMID: 30239557; PMCID: PMC6247336.
² Yuan W, Zheng B, Li T, Liu RH. Quantification of Phytochemicals, Cellular Antioxidant Activities and Antiproliferative Activities of Raw and Roasted American Pistachios (Pistacia vera L.). Nutrients. 2022; 14(15):3002. https://doi.org/10.3390/nu14153002
³ Wolfe KL, et al. Cellular Antioxidant Activity (CAA) Assay for Assessing Antioxidants, Foods, and Dietary Supplements. J Agric. Food Chem. 2007, 55, 8896–8907.
⁴ Song W, et al. Cellular Antioxidant Activity of Common Vegetables. J. Agric. Food Chem. 2010, 58, 6621–6629. DOI:10.1021/jf9035832
⁵ Wolfe, K., Kang, X., He, X., Dong, M., Zhang, Q., and Liu, R.H. Cellular antioxidant activity of common fruits. J. Agric. Food Chem. 56 (18): 8418-8426, 2008.

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The Alliance for Potato Research & Education is explicitly “Dedicated to advancing the scientific understanding of the role potatoes play in promoting the health of all people.”

As the Alliance explains:

Potatoes are a nutrient-rich vegetable and one of the top sources of potassium in Americans’ diets, yet they are often singled out as a food to limit. This recommendation is often based on misperceptions that eating potatoes is linked to increased cardiometabolic disease risk, even though potatoes contribute to overall fruit and vegetable consumption.  However, a newly published study in the Journal of Nutritional Science finds that advice may be unwarranted

Guess who sponsored that study.

• The study:  Potato consumption is not associated with cardiometabolic health outcomes in Framingham Offspring Study adults

• Conclusion: In this prospective cohort, there was no adverse association between fried or non-fried potato consumption and risks of T2DM/IFG, hypertension or elevated triglycerides.

• Funding: This work was supported by the National Heart, Lung and Blood Institute …with additional support from the Alliance for Potato Research and Education. The funders had no role in the design, analysis or writing of this article…The authors have declared that no conflict of interest.

Comment: We can argue about the effects of potatoes on insulin and blood sugar levels, a contentious issue because the ways they are cooked and prepared influence digestion of their starches to sugars and how quickly those sugars are absorbed.  But industry funding confuses the arguments, as it has a high probbility of inducing more than the usual level of bias into the results.  Much industry influence occurs at an unconscious level where it is unrecognized by rsearchers, so much so that they do not see it as a conflict of interest.  I think it is.

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The study:  Refined grain intake and cardiovascular disease: Meta-analyses of prospective cohort studies.  Glenn A.Gaesser.  Trends in Cardiovascular Medicine, Available online 6 September 2022.  https://doi.org/10.1016/j.tcm.2022.08.002

Conclusions:  Meta-analyses of prospective cohort studies demonstrate that refined grain intake is not associated with risk of CVD, stroke, or heart failure. This conclusion holds for studies that restricted analyses to staple grain foods only, as well as for studies that included both staple and indulgent grain foods as a single refined grains category. Although refined grains are included as a component of the Western dietary pattern, the present findings suggest that refined grains do not contribute to the higher CVD risk associated with this unhealthy dietary pattern. This information should be considered in formulation of future dietary recommendations.

Declaration of Competing Interest:  The author is a scientific advisory board member of the Grain Foods Foundation and the Wheat Foods Council.

Funding: Preparation of this manuscript was supported in part by a grant from the Grain Foods Foundation.

Comment: Refining of grains removes the outer bran and germ and most of the fiber and nutrients along with them, leaving some nutrients along with teh starch and protein.  Refined starch is quickly digested to sugars and rapidly absorbed.  The Wheat Foods Council wants to reassure you that you can eat as much refined grain as you like without raising disease risk.  Much independently funded research argues otherwise, alas.  If nothing else, refined grains contribute calories relatively low in nutrients and constitute major components of ultra-processed foods.  This study did not look at dietary patterns.

And thanks to David Ludwig for alerting me to this one.

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The publication date is tomorrow!

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I so appreciate the Obesity and Energetics newsletter that comes out every week, and particularly its occasional listing of “Headlines versus Study.”  This one is from a couple of months ago, but I am just getting to it.

• Headline: The Largest Study Ever on Avocados Has Some Good News for Your High Cholesterol: “Eating one avocado per day could lower LDL cholesterol and improve overall diet quality, according to a new study published in the Journal of the American Heart Association.”
• Press Release: Daily Avocados Improve Diet Quality, Help Lower Cholesterol Levels: “Eating one avocado a day for six months was found to have no effect on belly fat, liver fat or waist circumference in people with overweight or obesity, according to a new study. However, it did lead to a slight decrease in unhealthy cholesterol levels.  In the randomized trial, the team — including Penn State researchers — also found that participants who ate avocados had better quality diets during the study period.”
• Study Results: The primary outcome, change in visceral adipose tissue volume during the intervention period, was not significantly different between the Avocado Supplemented and Habitual Diet Groups…No significant group differences were observed for the secondary outcomes…Changes in the other additional and post hoc measures (body weight, body mass index, insulin, very low‐density lipoprotein concentrations, and total cholesterol:high‐density lipoprotein cholesterol ratio) were similar between the 2 groups.
• Conclusions:  Addition of 1 avocado per day to the habitual diet for 6 months in free‐living individuals with elevated waist circumference did not reduce visceral adipose tissue volume and had minimal effect on risk factors associated with cardiometabolic disorders.

This is a classic example of putting a favorable spin on no-effect results.  The study was NOT funded by the avocado industry and I cannot find a Haas Avocado Board comment on it.

The authors were quite clear about “no effect.” The press release is another matter.

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Coming soon!  My memoir, October 4.

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I very much appreciate the weekly newsletter, ObesityandEnergetics.org (If you want to subscribe, do so here).

I particularly enjoy its section, Headline vs Study.  Here’s the most recent, with my additions.

Headline: “Astonishing” Effects of Grape Consumption and “Remarkable” Impacts on Health and Lifespans.

Study: Grape Powder (Not Grapes) Modulates Gene Expression, Reduces Non-Alcoholic Fatty Liver Disease, and Extends Longevity… In Female Mice.

I took a look at the study.

• Conclusion: “These results suggest the potential of dietary grapes to modulate hepatic gene expression, prevent oxidative damage, induce fatty acid metabolism, ameliorate NAFLD (non-alcohol fatty liver disease), and increase longevity when co-administered with a high-fat diet.”
• Funding: This work was supported in part by the California Table Grape Commission. The sponsor was not involved: in the preparation of the article; in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.

Here is another study:

Study: Behavioral and Genetic Changes of Grape Powder (Not Grapes)… In Female Mice.

Its funding?  “This research was supported in part by the California Table Grape Commission.”

And one more:

Study: Grape Powder (Not Grapes) Modifies Hepatic and Urinary Metabolite Profiles… In Female Mice.

This study is also enlightening.

• Conflicts of interest: [onE of the authors] “serves on the scientific advisory board of the California Table Grape Commission. There are no other conflicts to declare.”
• Acknowledgements:  [two of the authors] “acknowledge grant support from the California Table Grape Commission and seed grant funding from Long Island University. The California Table Grape Commission was not involved: in the preparation of the article; in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.”

Comment:  As usual, these authors deny the problems inherent in industry funded studies that have marketing of health benefits as their primary purpose.  Grapes are fruits.  Fruits are healthy.  Do grapes perform health miracles?  Only if you believe in miracles.  Should you eat grapes?  Sure, if you like them.

You don’t believe this is about marketing?  Here’s one more headline (thanks to Karen Zornow Leiding for sending).  And you know who funded this.

Eating grapes can counteract harmful effects from processed foods, while boosting metabolism too

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Coming soon!  My memoir coming out in October.

For 30% off, go to www.ucpress.edu/9780520384156.  Use code 21W2240 at checkout.

Today’s Dietitian  sent this e-mail blast to members of the Academy of Nutrition and Dietetics on behalf of the National Pork Board, one of its sponsors.

The National Pork Board is seeking to build strong and meaningful partnerships with the Registered Dietitian profession. When it comes to up-to-date nutrition information, cooking techniques, continuing education and future collaborations, Pork is getting ready to give you the resources you value most. But first, we want to hear from you!

We invite you to take this survey for a chance to win one of fifteen $100 Amazon gift cards!*

The survey should take less than 15 minutes to complete. Your responses are voluntary and confidential. Responses will not be identified by individual but will be compiled and analyzed in aggregate.

Fifteen winners will be chosen at random to receive a $100 Amazon gift card. To be eligible, respondents must share their email address at the end of the survey.

Please click here to take the survey by August 22, 2022* Giveaway is subject to Official Rules.

If you want to know how meat trade associations encourage dietitians to promote their products, here’s an example.

Thanks to Dr. Lisa Young for alerting me to this one.

Two readers, Cory Brooks and Yme Dolmans, sent me this gem.

They learned about it from a story in The Guardian: “Jarlsberg cheese may help stave off osteoporosis, small study suggests.”

The Guardian picked this up from the BMJ, which published the study and sent out a press release: “Small daily portion of Jarlsberg cheese may help to stave off bone thinning.”

A small (57 g) daily portion of Jarlsberg cheese may help to stave off bone thinning (osteopenia/osteoporosis) without boosting harmful low density cholesterol, suggest the results of a small comparative clinical trial, published in the open access journal BMJ Nutrition Prevention & Health.

The effects seem to be specific to this type of cheese, the findings indicate.

Jarlsberg is a mild and semi-soft, nutty flavoured cheese made from cow’s milk, with regular holes. It originates from Jarlsberg in eastern Norway.

Eat Jarlsberg cheese and prevent osteoporosis?  A miracle!

As with any other study claiming that a single food produces health miracles, my first question: Who paid for this?

The paper:  Effect on bone anabolic markers of daily cheese intake with and without vitamin K₂: a randomised clinical trial.  

Conclusion.  The effect of daily Jarlsberg intake on increased s-osteocalcin level is not a general cheese effect. Jarlsberg contain vitamin K₂ and DHNA which increases PINP, tOC, cOC and R_O and decreases Ca⁺⁺, Mg⁺⁺ and HbA1c. These effects reflect increased bone anabolism and a possible reduced risk of adverse metabolic outcomes.

Funding:  Norwegian Research Council; project number 310059, TINE SA, and Meddoc Research Unit funded this project.

Contributors: TINE SA provided Jarlsberg and Camembert cheese, along with financial support, but did not play any role in the design, implementation, analysis, interpretation or manuscript writing.

Comment:  This study is the result of a private-public partnership between the Norwegian government and its dairy industry.  The Norwegian Research Council provides research funding for industry: “We promote competitiveness and growth in Norwegian trade and industry by providing financial support and advice for research and innovation projects.”

As for TINE SA, it  “is Norway’s largest producer, distributor and exporter of dairy products with 11,400 members (owners) and 9,000 cooperative farms.”

This situation is analogous to USDA’s Agricultural Marketing Service’s research partnerships with food trade associations; these also produce studies with results that the press loves to extol and funders can use for marketing.

The purpose of this study is to support a Norwegian industry by promoting sales of Jarlsberg.

Is it likely that eating a couple of ounces of Jarlsberg would have much of an effect on osteoporosis?

The operative word here is “may.”   This could also mean “may not.”

The bottom line:  If you like Jarlsberg cheese, enjoy!

One of the points of my Monday “industry-funded study of the week” posts is that companies usually get the results they want.  Exceptions do exist.  Here’s one of those rare ones.

The study: Changes in Biomarkers of Non-Alcoholic Fatty Liver Disease (NAFLD) upon Access to Avocados in Hispanic/Latino Adults: Secondary Data Analysis of a Cluster Randomized Controlled Trial.  Lorena S. Pacheco, Ryan D. Bradley, Cheryl A. M. Anderson and Matthew A. Allison.  Nutrients 2022, 14(13), 2744; https://doi.org/10.3390/nu14132744

Rationale: Non-alcoholic fatty liver disease (NAFLD) is a common cause of abnormal liver functions tests and of increased increased risk for morbidity and mortality.  Monounsaturated fatty acids such as those in avocados havew been associated with improved NAFLD-related markers.

Hypothesis: “We hypothesized compared to low avocado intake, high avocado intake would have a beneficial effect on oxidative stress and hepatic health indicated by greater reductions in liver function tests and NAFLD fibrosis score.”

Results: “No statistically significant differences were observed between low and high avocado allotment groups” in anything measured.

Conclusion: “Varied intake of avocados resulted in no effects on biomarkers of NAFLD in healthy adults, free of severe chronic disease.”

Funding: “The parent research was funded by The Hass Avocado Board.”

Conflicts of interest: “The authors declare no potential conflict of interest. All authors report the grant from the Hass Avocado Board….The Hass Avocado Board funded the parent trial and provided all the trial’s avocados at no cost to study participants. The parent trial funder had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.”

Comment: The authors say they have no conflicts of interest but I think they do; the Hass Avocado Board paid for a study of the effects of avocados on NAFLD markers.  Such payments are well established to predict results that favor the sponsor’s interests.

Nevertheless, the results came out contrary to those interests, and the authors were unambiguous in saying so.  In this case, the assertion that the sponsor had no role seems credible, even though it often is not.

High marks to the authors.